Erythropoietin receptor/EpoR 蛋白, Mouse (sf9, Fc)

Erythropoietin receptor (EpoR) mediates erythropoietin-induced erythroblast proliferation and differentiation. After EPO stimulation, EpoR dimerizes, initiates the JAK2/STAT5 signaling cascade, and can activate STAT1, STAT3, and LYN tyrosine kinases in certain cell types. Erythropoietin receptor/EpoR Protein, Mouse (sf9, Fc) is the recombinant mouse-derived Erythropoietin receptor/EpoR protein, expressed by Sf9 insect cells , with C-hFc labeled tag. The total length of Erythropoietin receptor/EpoR Protein, Mouse (sf9, Fc) is 249 a.a., with molecular weight of ~58.6 kDa.

促红细胞生成素受体 (EpoR) 是促红细胞生成素的关键受体，在 EPO 刺激下协调成红细胞增殖和分化。通过 EpoR 二聚化，它启动 JAK2/STAT5 信号级联，导致各种细胞反应。除了激活特定细胞类型中的 STAT1 和 STAT3 之外，EpoR 还可能参与 LYN 酪氨酸激酶。EPO 结合后，EpoR 形成同二聚体并经历酪氨酸磷酸化，促进与多种含 SH2 结构域的蛋白质（如 LYN、APS、PTPN6、PTPN11、JAK2、PI3 激酶、STAT5A/B、SOCS3、CRKL 和 ATXN2L）相互作用。这些复杂且多方面的相互作用调节下游信号传导事件，包括有丝分裂途径和细胞表面表达。值得注意的是，EpoR 与 NOSIP 和泛素连接酶 NOSIP 的相互作用与 EPO 诱导的细胞增殖有关，凸显了 EpoR 介导的信号传导的调节复杂性。此外，EpoR 与 FSFFV gp55 形成异源寡聚物，并与 INPP5D/SHIP1 结合，进一步扩展其在细胞过程中的功能库。

Mouse

Sf9 insect cells

C-hFc

P14753 (M1-P249)

13857  [NCBI]

MDKLRVPLWPRVGPLCLLLAGAAWAPSPSLPDPKFESKAALLASRGSEELLCFTQRLEDLVCFWEEAASSGMDFNYSFSYQLEGESRKSCSLHQAPTVRGSVRFWCSLPTADTSSFVPLELQVTEASGSPRYHRIIHINEVVLLDAPAGLLARRAEEGSHVVLRWLPPPGAPMTTHIRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRARMAEPSFSGFWSAWSEPASLLTASDLDP

Approximately 58.6 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.