FGF-1 蛋白, Human

FGF-1 Protein, Human is a growth factor and signaling protein encoded by the FGF1 gene.

酸性成纤维细胞生长因子涉及广泛的生物学功能，包括组织发育和修复、血管生成、上皮细胞和间质细胞的增殖以及肿瘤发生。酸性成纤维细胞生长因子的生物活性取决于与高度特异性的细胞表面受体的结合，其中成纤维细胞生长因子受体 4 (FGFR4) 具有高度特异性^[1]。

The ED₅₀ is <0.3 ng/mL, measured by a cell proliferation assay of 3T3 Cells, corresponding to a specific activity of > 3.3 × 10⁶ IU/mg in the presence of 10.0 μg/ml of heparin.

• 
  The ED₅₀ is 0.01025 ng/mL, measured by a cell proliferation assay of 3T3 Cells, corresponding to a specific activity of 9.76×10⁷ IU/mg in the presence of 10.0 μg/ml of heparin.

Human

E. coli

Tag Free

P05230 (F16-D155)

2246  [NCBI]

FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD

15-18 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS or 20 mM PB, 150 mM NaCl, pH 6.8.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. La Rosa S, et al. Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. J Clin Pathol. 2001 Jan;54(1):37-41.  [Content Brief]