FGF-18 蛋白, Mouse

FGF-18 Protein, Mouse is a trophic factor for mature chondrocytes and their progenitors.

小鼠成纤维细胞生长因子-18 (FGF18) 是成熟软骨细胞及其祖细胞的营养因子^[1]。据报道，FGF18 对软骨具有显着的合成代谢作用。FGF18 在骨骼生长和发育中发挥着核心作用。缺乏 Fgf18 的小鼠表现出软骨和骨骼畸形，包括颅骨缝闭合延迟、长骨生长板增殖和肥大区扩大、关节发育缺陷以及成骨分化延迟^{[2]< /sup>。}

The ED₅₀ is <0.5 μg/mL as measured by 3T3 cells, corresponding to a specific activity of >2.0 × 10³ units/mg.

Mouse

E. coli

Tag Free

O89101 (E28-G207)

14172  [NCBI]

EENVDFRIHVENQTRARDDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPRKGPKTRENQQDVHFMKRYPKGQAELQKPFKYTTVTKRSRRIRPTHPG

Approximately 20.1 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Ellsworth JL, et al. Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors. Osteoarthritis Cartilage. 2002 Apr;10(4):308-20.  [Content Brief]

  [2]. Moore EE, et al. Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthritis Cartilage. 2005 Jul;13(7):623-31.  [Content Brief]