FLT3 蛋白, Human (T227M, HEK293, His)

FLT3, a tyrosine-protein kinase receptor, regulates hematopoietic progenitor cells and dendritic cells' differentiation, proliferation, and survival. It phosphorylates downstream effectors like SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. Additionally, it plays a pivotal role in the phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A/B. Wild-type FLT3 activation modestly activates STAT5A or STAT5B, while constitutive kinase mutations heighten cell proliferation and resist apoptosis, highlighting its role in fostering aberrant signaling pathways. FLT3 Protein, Human (T227M, HEK293, His) is the recombinant human-derived FLT3 protein, expressed by HEK293 , with C-His labeled tag and T227M mutation. The total length of FLT3 Protein, Human (T227M, HEK293, His) is 515 a.a., with molecular weight of 85-95 kDa.

FLT3 是一种酪氨酸蛋白激酶，作为细胞因子 FLT3LG 的细胞表面受体发挥作用，对造血祖细胞和树突状细胞的分化、增殖和存活进行调节控制。该受体促进各种下游效应子的磷酸化，包括 SHC1 和 AKT1，并激活涉及 MTOR、RAS、MAPK1/ERK2 和/或 MAPK3/ERK1 的信号级联。此外，它在 FES、FER、PTPN6/SHP、PTPN11/SHP-2、PLCG1 以及 STAT5A 和/或 STAT5B 的磷酸化中发挥关键作用。虽然野生型 FLT3 激活会导致 STAT5A 或 STAT5B 适度激活，但引起组成型激酶活性的突变会导致细胞增殖增强和细胞凋亡抵抗力增强，从而强调了其在促进异常信号传导途径中的作用。

Human

HEK293

C-His

P36888-1 (N27-N541, T227M)

2322  [NCBI]

85-95 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.