FLT3 蛋白, Mouse (HEK293, His)

FLT3, a receptor tyrosine kinase, has diverse functions including kinase activation, PI3K binding, and ligase binding. It plays a vital role in hematopoiesis, immune function, and tissue development. FLT3 is expressed in various tissues like the brain, immune system, and reproductive system. It is involved in diseases like leukemia and cancer. The wide functions and tissue-specific expression emphasize FLT3's importance in health and disease. FLT3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLT3 protein, expressed by HEK293 , with C-His labeled tag. The total length of FLT3 Protein, Mouse (HEK293, His) is 517 a.a., with molecular weight of approximately 88-100 kDa.

FLT3 是一种受体酪氨酸激酶，具有多种功能，包括磷脂酰肌醇 3-激酶结合、蛋白酪氨酸激酶活性和泛素蛋白连接酶结合。它参与骨髓祖细胞增殖、造血和淋巴细胞增殖等关键过程，凸显了它在造血发育和免疫系统功能中的重要作用。FLT3 位于质膜外侧，在多种组织中表现出偏向表达，包括大脑、背主动脉、免疫和生殖系统以及脊髓。该蛋白在急性髓性白血病和幼年粒单核细胞白血病等疾病中发挥着重要作用，其直系同源物与急性淋巴细胞白血病、结直肠腺癌、肝细胞癌和前列腺癌等疾病有关。多方面的功能和组织特异性表达强调了 FLT3 在细胞稳态和疾病进展中的重要性。

Measured by its binding ability in a functional ELISA. Immobilized human Flt-3 Ligand, at 1 μg/mL (100 μL/well) can bind Biotinylated Mouse FLT3 protein. The ED50 for this effect is 5.987 ng/mL.

• 
  Measured by its binding ability in a functional ELISA. Immobilized human Flt-3 Ligand, at 1 μg/mL (100 μL/well) can bind Biotinylated Mouse FLT3 protein. The ED₅₀ for this effect is 5.987 ng/mL.

Mouse

HEK293

C-His

NP_034359.2 (N28-S544)

14255  [NCBI]

approximately 88-100 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.