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  3. GABARAPL1/GEC-1 蛋白, Human (His)

GABARAPL1/GEC-1 蛋白, Human (His)

目录号: HY-P70913
COA 产品使用指南

GABARAPL1/GEC-1 是一种多功能泛素样修饰剂,有助于 kappa 型阿片受体的细胞表面表达,并有助于自噬,塑造自噬体液泡。与参与吞噬细胞延伸的 LC3 不同,GABARAP/GATE-16 亚家族在自噬体晚期成熟中发挥着至关重要的作用。GABARAPL1/GEC-1 蛋白, Human (His) 是重组的 GABARAPL1/GEC-1 蛋白,由 E. coli 表达,带有 N-6*His 标签。GABARAPL1/GEC-1 蛋白, Human (His) 全长 117 个氨基酸,分子量约为 ~20.0 kDa。

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10 μg ¥1150 In-stock
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100 μg ¥5400 In-stock
500 μg ¥12000 In-stock
1 mg ¥17000 In-stock
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描述

GABARAPL1/GEC-1 is a multifunctional ubiquitin-like modifier that contributes to cell surface expression of kappa-type opioid receptors and contributes to autophagy, shaping autophagosome vacuoles. Unlike LC3, which is involved in phagophore elongation, the GABARAP/GATE-16 subfamily plays a crucial role in late autophagosome maturation. GABARAPL1/GEC-1 Protein, Human (His) is the recombinant human-derived GABARAPL1/GEC-1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GABARAPL1/GEC-1 Protein, Human (His) is 117 a.a., with molecular weight of ~20.0 kDa.

研究背景

GABARAPL1/GEC-1 是一种泛素样修饰剂,在细胞过程中发挥多方面的作用。它通过促进 kappa 型阿片受体的顺行细胞内运输来增强其细胞表面表达。此外,GABARAPL1/GEC-1 有助于自噬,参与自噬体液泡的形成。虽然 LC3 与吞噬细胞膜伸长相关,但 GABARAP/GATE-16 亚家族在自噬体成熟的后期阶段发挥着至关重要的作用。此外,GABARAPL1/GEC-1与网状吞噬受体TEX264合作,在营养应激期间将内质网的子结构域重塑为自噬体,促进随后与溶酶体的融合以实现内质网周转。该蛋白参与与各种伙伴的相互作用网络,包括 ATG13、OPRK1、RB1CC1、ULK1、TP53INP1、TP53INP2、SQSTM1、ATG3、ATG7、MAP15、TECPR2、TBC1D5、MAPK15、TRIM5、MEFV、TRIM21、WDFY3、UBA5、KBBTD6 、KBTBD7、RETREG1、RETREG2、RETREG3、TEX264 和 IRGM,强调了其在细胞稳态和自噬过程中的重要性。

种属

Human

表达系统

E. coli

标签

N-6*His

蛋白编号

Q9H0R8 (M1-K117)

基因 ID
蛋白结构
N-term
6*His
GABARAPL1 (M1-K117)
Accession # Q9H0R8
C-term
同用名
Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 1; Early Estrogen-Regulated Protein; GABA(A) Receptor-Associated Protein-Like 1; Glandular Epithelial Cell Protein 1; GEC-1; GABARAPL1; GEC1
氨基酸序列

MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK

分子量

Approximately 20.0 kDa

纯度
  • Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of sterile 50 mM Tris-HCL, 300 mM NaCl, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween 80.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

GABARAPL1/GEC-1 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
GABARAPL1/GEC-1 Protein, Human (His)
目录号:
HY-P70913
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