GGACT 蛋白, Human (HEK293, His)

The GGACT protein uses its enzymatic activity to break cross-links between lysine and glutamate residues, actively promoting the degradation of proteins cross-linked by transglutaminase. In addition, GGACT catalyzes the formation of 5-oxo-L-proline from the substrate L-γ-glutamyl-L-ε-lysine. GGACT Protein, Human (HEK293, His) is the recombinant human-derived GGACT protein, expressed by HEK293 , with N-6*His labeled tag. The total length of GGACT Protein, Human (HEK293, His) is 153 a.a., with molecular weight of ~18.0 kDa.

GGACT（γ-谷氨酰胺环转移酶），也称为 5-氧代脯氨酸酶，通过裂解赖氨酸和谷氨酸残基之间的交联，在转谷氨酰胺酶交联的蛋白质降解中发挥着至关重要的作用。此外，GGACT 催化 L-γ-谷氨酰-L-ε-赖氨酸形成 5-氧代-L-脯氨酸。值得注意的是，GGACT 对 L-γ-谷氨酰-L-α-半胱氨酸和 L-γ-谷氨酰-L-α-丙氨酸等底物表现出不活性，表明其酶活性具有底物特异性。该酶针对特定交联蛋白质结构的能力凸显了其在与蛋白质周转和降解相关的细胞过程中的重要性。

Human

HEK293

N-6*His

Q9BVM4 (M1-R153)

87769  [NCBI]

MALVFVYGTLKRGQPNHRVLRDGAHGSAAFRARGRTLEPYPLVIAGEHNIPWLLHLPGSGRLVEGEVYAVDERMLRFLDDFESCPALYQRTVLRVQLLEDRAPGAEEPPAPTAVQCFVYSRATFPPEWAQLPHHDSYDSEGPHGLRYNPRENR

Approximately 18.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.