glycoprotein/G 蛋白, HRSV (sf9, His)

The glycoprotein/G Protein, crucial in the immune response, forms the interleukin-31 receptor with OSMR. This receptor activates STAT3, and to a lesser extent, STAT1 and STAT5, playing a vital role in skin immunity and mediating IL31-induced itch, potentially involving TRPA1 and TRPV1. It positively regulates myeloid progenitor cell numbers and cycling status in the bone marrow, enhancing survival. Acting in viral infection, the glycoprotein/G Protein attaches the virion to the host cell membrane, interacts with heparan sulfate, modulates the immune response through CX3CR1, and aids in escaping antibody-dependent restriction by acting as an antigen decoy. glycoprotein/G Protein, HRSV (sf9, His) is the recombinant Virus-derived glycoprotein/G protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of glycoprotein/G Protein, HRSV (sf9, His) is 232 a.a., with molecular weight of 40-55 kDa.

糖蛋白/G 蛋白是免疫反应的重要组成部分，通过与 OSMR 结合形成白细胞介素 31 受体。该受体在激活 STAT3 以及较小程度上激活 STAT1 和 STAT5 中发挥着至关重要的作用。已知它参与皮肤免疫，并可能通过依赖阳离子通道 TRPA1 和 TRPV1 介导 IL31 引起的瘙痒。此外，无论在体内还是体外，糖蛋白/G蛋白都能积极调节骨髓中未成熟的髓系祖细胞亚群的数量和循环状态，从而增强髓系祖细胞的存活率。它与 OSMR 形成异二聚体，并与 JAK1 和 STAT3 相互作用以执行其功能。在病毒感染方面，这种糖蛋白/G蛋白通过与硫酸乙酰肝素相互作用将病毒颗粒附着在宿主细胞膜上，启动感染过程。它还与宿主 CX3CR1（CX3C 趋化因子 fractalkine 的受体）相互作用，调节免疫反应并促进感染。与其他副粘病毒附着蛋白不同，它缺乏神经氨酸酶和血凝活性。此外，它还可以充当抗原诱饵并调节带有 Fc-gamma 受体的白细胞的活性，帮助病毒逃避抗体依赖性复制限制。

Virus

Sf9 insect cells

C-His

P27022 (N66-R297)

/

40-55 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.