HAI-2 蛋白, Human (HEK293, His)

HAI-2 protein is a multifunctional inhibitor that regulates multiple cellular processes by potently inhibiting HGFAC and reducing serine protease activity, specifically TMPRSS13 and ST14/matriptase. HAI-2 is good at inhibiting plasmin, plasma and tissue kallikrein, with broad-spectrum inhibitory capabilities. HAI-2 Protein, Human (HEK293, His) is the recombinant human-derived HAI-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HAI-2 Protein, Human (HEK293, His) is 170 a.a., with molecular weight of 24-30 kDa.

HAI-2 是一种具有多方面抑制作用的多功能蛋白质，在多种细胞过程中成为有效的调节剂。其抑制能力延伸至 HGFAC，充当针对其活动的强大哨兵。除此之外，HAI-2 还表现出了抑制纤溶酶以及血浆和组织激肽释放酶的能力，凸显了其广谱抑制能力。值得注意的是，HAI-2 是丝氨酸蛋白酶活性的关键调节剂，在体外抑制 TMPRSS13 和 ST14/matriptase 的功能。分子相互作用的复杂舞蹈包括与 TMPRSS13 的直接结合，精心策划的相互作用不仅抑制而且促进这种丝氨酸蛋白酶的磷酸化和细胞定位。从本质上讲，HAI-2 是一个多才多艺的守护者，复杂地引导细胞景观，微调丝氨酸蛋白酶活性并在各种生理环境中保持微妙的平衡。

Human

HEK293

C-6*His

O43291 (A28-K197)

10653  [NCBI]

ADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSK

24-30 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.