1. 重组蛋白
  2. Cytokines and Growth Factors CAR-T related Proteins Receptor Proteins Enzymes & Regulators
  3. HGF & Receptors c-Met/HGFR Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. HGFR 蛋白, Rat (HEK293, Fc)

HGFR 蛋白, Rat (HEK293, Fc)

目录号: HY-P72942
COA 产品使用指南

HGFR 蛋白是一种受体酪氨酸激酶,通过与肝细胞生长因子/HGF 配体结合,充当细胞外基质的信号转导器。HGFR 蛋白参与 RAS-ERK、PI3 激酶-AKT 和 PLCgamma-PKC 信号通路的激活。HGFR 蛋白对于胚胎发育、器官发生和伤口愈合至关重要。HGFR 蛋白, Rat (HEK293, Fc) 是重组的 HGFR 蛋白,由 HEK293 表达,带有 C-hFc 标签。HGFR 蛋白, Rat (HEK293, Fc) 全长 908 个氨基酸,分子量分别约为 ~97 & 39 kDa。

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2 μg ¥370 In-stock
10 μg ¥730 In-stock
50 μg ¥1470 In-stock
100 μg ¥2200 In-stock
500 μg ¥5500 In-stock
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描述

HGFR Protein is a receptor tyrosine kinase that acts as a signal transducer of the extracellular matrix by binding to hepatocyte growth factor /HGF ligands. HGFR Protein participate in the activation of RAS-ERK, PI3 kinase-AKT, and PLCgamma-PKC signaling pathways. HGFR Protein is essential for embryonic development, organogenesis, and wound healing. HGFR Protein, Rat (HEK293, Fc) is the recombinant rat-derived HGFR protein, expressed by HEK293, with C-hFc labeled tag. The total length of HGFR Protein, Rat (HEK293, Fc) is 908 a.a., with molecular weight of ~97 & 39 kDa, respectively.

研究背景

FITC 标记的 HGFR 蛋白是一种受体酪氨酸激酶,通过与肝细胞生长因子/HGF 配体结合,充当细胞外基质的信号转导器。它在调节多种生理过程中发挥着关键作用,包括增殖、散射、形态发生和细胞存活。配体在细胞表面结合后,FITC 标记的 HGFR 在其胞内结构域上发生自磷酸化,为下游信号分子创建对接位点。被配体激活后,它与 PI3 激酶亚基 PIK3R1、PLCG1、SRC、GRB2、STAT3 或适配器 GAB1 相互作用,导致多个信号级联的激活,包括 RAS-ERK、PI3 激酶-AKT 和 PLCgamma- PKC。RAS-ERK 激活与形态发生效应相关,而 PI3K/AKT 协调促生存效应。在胚胎发育中,FITC 标记的 HGFR 信号传导有助于原肠胚形成、神经元前体的发育和迁移、血管生成和肾脏形成。在骨骼肌发育过程中,它对于肌肉祖细胞的迁移和次级成肌细胞的增殖至关重要。在成人中,它参与伤口愈合、器官再生、组织重塑,并促进造血细胞的分化和增殖。此外,在微生物感染的情况下,FITC 标记的 HGFR 充当单核细胞增生李斯特菌 InlB 内的受体,介导病原体进入细胞[1][2][3][4]

生物活性

Immobilized Human HGF at 2 μg/mL (100 μL/well) can bind Rat HGFR. The ED50 for this effect is 23.11 ng/mL.

种属

Rat

表达系统

HEK293

标签

C-hFc

蛋白编号

Q2IBC7 (E25-N932)

基因 ID
蛋白结构
N-term
HGFR (E25-N932)
Accession # Q2IBC7
hFc
C-term
同用名
Hepatocyte growth factor receptor; HGF receptor; SF receptor; MET
氨基酸序列

ECKEALVKSEMNVNMKYQLPNFTAETPIHNVVLHGHHIYLGATNYIYVLDDKDLQKVSEFKTGPVVEHPDCFPCQDCSSKANVSGGVWKDNVNMALLVDTYYDDQLISCGSVNRGTCQRHVLPPDNAADIQSEVHCMFSPLAEEESGQCPDCVVSALGAKVLLSEKDRFINFFVGNTINSSYPPDYSLHSISVRRLKETQDGFKFLTDQSYIDVLPEFRDSYPIKYIHAFESNHFIYFLTVQKETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQIGASPYDDILYGVFAQSKPDSAEPMNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRSDEYRTEFTTALQRVDLFMGRLNHVLLTSISTFIKGDLTIANLGTSEGRFMQVVLSRTAHFTPHVNFLLDSYPVSPEVIVEHPSNQNGYTLVVTGKKITKIPLNGLGCGHFQSCSQCLSAPYFIQCGWCHNRCVHSNECPSGTWTQEICLPAVYKVFPTSAPLEGGTMLTICGWDFGFKKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIVSNSRETTQYSAFSYVDPVITSISPRYGPHAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPGHTVSAEFPVKLKIDLADRVTSSFSYREDPVVSEIHPTKSFISGGSTITGIGKNLNSVSTPKLVIEVHDVGVNYTVACQHRSSSEIICCTTPSLQQLDLQLPLKTKAFFLLDGILSKHFDLTYVHDPMFKPFEKPVMISMGNENVVEIKGDDIDPEAVKGEVLKVGNKSCENLHWHSEALLCTVPSDLLKLNGGELNIEWKQAVSSTVLGKVIVQPDQN

分子量

Approximately 40-43&100-110 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
HGFR Protein, Rat (HEK293, Fc)
目录号:
HY-P72942
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