Met - MET proto-oncogene, receptor tyrosine kinase Gene

中文名称：MET 原癌基因， 受体酪氨酸激酶

种属: Rattus norvegicus

同用名: Hgfr

关于 Met

功能概要

该基因编码的蛋白可启动多种功能，包括 β-连环蛋白结合活性；肝细胞生长因子激活受体活性；和磷脂酶结合活性。参与多个过程，包括动物器官发育；神经系统发育；和大分子代谢过程的正向调控。位于多个细胞成分中，包括突触后密度；突触后膜；和精子鞭毛。多种疾病的生物标志物，包括急性肾功能衰竭；肝胆系统癌（多发性）；肝脏良性肿瘤;胰腺炎;和牙周炎。该基因的人类直系同源物与自闭症有关；常染色体隐性非综合征性耳聋 97；癌（多发性）；和多发性骨髓瘤。与人类 MET 同源（MET 原癌基因，受体酪氨酸激酶）。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including beta-catenin binding activity; hepatocyte growth factor-activated receptor activity; and Phospholipase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of macromolecule metabolic process. Located in several cellular components, including postsynaptic density; postsynaptic membrane; and sperm flagellum. Biomarker of several diseases, including acute kidney failure; hepatobiliary system Cancer (multiple); liver benign neoplasm; pancreatitis; and periodontitis. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]