HLA-A*0201 HPV16 E7 complex 蛋白, Human (YMLDLQPET, HEK293, His-Avi)

The HLA-A*0201 HPV16 E7 complex, part of the MHCI family, is central to immune recognition. Associated with β2 microglobulin, it presents viral and tumor peptides on antigen-presenting cells for CD8-positive T cell recognition. This interaction guides antigen-specific T cell responses against infected or transformed cells. The complex's diverse repertoire includes self-peptides and varies in peptide length, contributing to antigen specificity. HLA-A*0201, representing this complex, presents viral and tumor-associated epitopes, highlighting its pivotal role in immune responses against pathogens and cancer. HLA-A*0201 HPV16 E7 complex Protein, Human (YMLDLQPET, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-A*0201 and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and YMLDLQPET peptide. HLA-A*0201 HPV16 E7 complex Protein, Human (YMLDLQPET, HEK293, His-Avi), has molecular weight of 53-63 kDa.

HLA-A*0201 HPV16 E7 复合体是抗原呈递主要组织相容性复合体 I 类 (MHCI) 家族的成员，在免疫识别和反应中发挥着关键作用。当与 β2 微球蛋白 (B2M) 结合时，它主要在抗原呈递细胞表面呈递病毒和肿瘤衍生肽，促进 CD8 阳性 T 细胞通过其 α-β T 细胞受体 (TCR) 进行识别。这种相互作用引导抗原特异性 T 细胞免疫反应，这对于消除感染或转化的细胞至关重要。除了病毒肽之外，它还可能呈现源自分泌蛋白或膜蛋白的信号序列的自身肽。该复合物展示了多种细胞内肽抗原，长度通常为 8 至 13 个氨基酸，通过免疫蛋白酶体或胰岛素降解酶进行处理。由特定锚定残基定义的不同肽的结合有助于抗原识别的精细特异性。值得注意的是，代表性等位基因 HLA-A*0201 呈现出限制性肽库，包括流感和 SARS-CoV-2 的病毒表位，以及肿瘤相关抗原，例如 MAGE1、MAGEA3 和 WT1。肽呈递的复杂性凸显了该 MHCI 复合物在协调针对各种病原体和癌细胞的免疫反应中的关键作用。

Human

HEK293

C-Avi;C-His

P04439-1 (G25-T305)&P61769 (I21-M119)&YMLDLQPET

/&567

53-63 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.