1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interferon & Receptors
  4. IFN-alpha
  5. IFN-alpha 1
  6. IFN-alpha 13/IFNA1 蛋白, Human (P.pastoris, His)

IFN-alpha 13/IFNA1 蛋白, Human (P.pastoris, His)

目录号: HY-P73245
COA 产品使用指南

IFN-alpha 13 (IFNA1) 属于 I 型干扰素家族,由巨噬细胞产生,具有抗病毒活性。IFN-alpha 1 参与了 JAK1/TYK2 通路,通过抑制病毒复制和调节免疫反应发挥作用。重组人 IFN-alpha 13/IFNA1 蛋白 (P.pastoris, His) 由 P.pastoris 酵母细胞产生,带有 C 末端 His 标签。

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描述

IFN-alpha 13 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities[1]. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway[4], exerts function by inhibiting viral replication as well as modulating immune response[3]. IFN-alpha 13/IFNA1 Protein, Human (P.pastoris, His) is produced in P.pastoris yeast cells with a C-Terminal His-tag.

研究背景

IFN-α 1(IFNA1;IFN-α1)属于 α/β 干扰素家族,由巨噬细胞产生,具有抗病毒活性[1]。干扰素(IFN)最初被认为是一种在体外“干扰”病毒复制的物质。IFN-α/β及相关分子被归类为I型干扰素,其他两类分别为II型干扰素(IFN-γ)和III型干扰素(IFN-λ)[2]
IFN 与三种类型特异性受体之一结合,从而激活 JAK1TYK2[3]。这种信号转导导致 STAT1 和 STAT2 磷酸化,并最终与 IFN 调节因子 9 (IRF9) 相关并形成 IFN 刺激的基因因子 3 (ISGF3) 复合物。因此,ISGF3 复合物诱导 IFN 刺激基因 (ISG) 的转录,随后对先天性和适应性免疫反应产生免疫调节作用[4]
I 型 IFN 与免疫系统的相互作用系统通过其对树突状细胞 (DC) 的影响,对于产生持久的抗肿瘤反应非常重要[5]。IFN已广泛用于动物疾病模型,人IFNA1蛋白氨基酸序列与小鼠有很大差异(62.96%)。

体外研究
(In Vitro)

IFN-alpha induces highly active dendritic cells (DC) rapidly generated from blood monocytes in vitro, suitable for therapeutic vaccination of cancer research[5].

种属

Human

表达系统

P. pastoris

标签

C-His

蛋白编号

P01562 (C24-E189)

基因 ID

3439  [NCBI]/3447  [NCBI]

蛋白结构
N-term
IFNA1 (C24-E189)
Accession # P01562
His
C-term
中文名
重组人 IFN-alpha 13/IFNA1 蛋白 (P.pastoris, His)
同用名
Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1; IFNA13
分子量

Approximately 20.8 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
参考文献

IFN-alpha 13/IFNA1 Protein, Human (P.pastoris, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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