1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interferon & Receptors
  4. IFN-α/β Receptor
  5. IFN-alpha/beta R2
  6. IFN-alpha/beta R2 蛋白, Human (HEK293, His, solution)

IFN-alpha/beta R2 蛋白, Human (HEK293, His, solution)

目录号: HY-P74862A
COA 产品使用指南

IFN-α/β R2 蛋白与 IFNAR1 形成异二聚体,并充当 I 型干扰素的受体。干扰素结合后,受体亚基激活 JAK,导致 STAT 转录因子磷酸化。IFN-alpha/beta R2 蛋白, Human (HEK293, His, solution) 是重组的 IFN-α/β R2 蛋白,由 HEK293 表达,带有 C-His 标签。IFN-alpha/beta R2 蛋白, Human (HEK293, His, solution) 全长 217 个氨基酸,分子量约为 ~45 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
Free Sample   Apply now  
2 μg ¥670 In-stock
10 μg ¥1880 In-stock
50 μg ¥5250 In-stock
100 μg   询价  

* Please select Quantity before adding items.

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

IFN-α/β R2 protein forms a heterodimer with IFNAR1 and acts as a receptor for type I interferons. After interferon binding, the receptor subunit activates JAK, leading to the phosphorylation of STAT transcription factors. IFN-alpha/beta R2 Protein, Human (HEK293, His, solution) is the recombinant human-derived IFN-alpha/beta R2 protein, expressed by HEK293 , with C-His labeled tag. The total length of IFN-alpha/beta R2 Protein, Human (HEK293, His, solution) is 217 a.a., with molecular weight of ~45 kDa.

研究背景

IFN-α/β R2 蛋白与 IFNAR1 一起构成异二聚体受体,负责识别 I 型干扰素,包括干扰素 α、β、ε、omega 和 kappa。I 型干扰素结合后,IFNAR1 和 IFNAR2 亚基非常接近,促进与每个亚基相关的 Janus 激酶 (JAK) 的激活(TYK2 与 IFNAR1 结合,JAK1 与 IFNAR2 结合)。这种激活涉及 JAK 的交叉磷酸化,进而磷酸化 IFNAR1 和 IFNAR2 胞内结构域上的特定酪氨酸残基。这些磷酸化位点充当 STAT 转录因子(STAT1、STAT2 和 STAT3)的对接位点,启动信号级联反应,导致 STAT 蛋白易位到细胞核中。易位的 STAT 蛋白调节干扰素调节基因的表达,有助于干扰素反应。从机制上讲,IFN-α/β R2 可作为 I 型 IFN 受体活性的有效抑制剂,调节干扰素信号传导的下游效应。

生物活性

Measured by its ability to inhibit rh IFNβ mediated protection of WISH Human amnion cells infected with vesicular stomatitis virus (VSV) to viral lysis and the EC50 is typically <4 μg/mL.

种属

Human

表达系统

HEK293

标签

C-His

蛋白编号

P48551 (I27-K243)

基因 ID
蛋白结构
N-term
IFNAR2 (I27-K243)
Accession # P48551
His
C-term
中文名
重组人 IFN-alpha/beta R2 蛋白
同用名
Interferon alpha/beta receptor 2; IFN-R-2; Interferon alpha binding protein; IFNAR2; IFNABR; IFNARB
分子量

Approximately 45 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

溶液.

组分

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

N/A.

保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.

文件资料

IFN-alpha/beta R2 Protein, Human (HEK293, His, solution) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
IFN-alpha/beta R2 Protein, Human (HEK293, His, solution)
目录号:
HY-P74862A
需求量: