IGF-I/IGF-1 蛋白, Rat

IGF-I/IGF-1 Protein, Rat has somatomedin activity and ability to potently promote neuronal survival.

IGF-I（胰岛素样生长因子-I）具有生长调节素活性。IGF-I 以剂量依赖性方式刺激垂体切除大鼠的生长^[1]。循环中的 IGF-I 通过介导生长激素的间接作用，在正常生长和发育中发挥着重要作用，与生长激素有着复杂的关系。将 IGF-I 递送至中枢神经系统可能有益于治疗阿尔茨海默氏病或中风，因为 IGF-I 能够有效促进神经元存活、拯救海马神经元免受 β-淀粉样蛋白诱导的神经毒性、减少 tau 磷酸化、保护皮质神经元免受硝酸的侵害。氧化物介导的神经毒性，将神经元从葡萄糖剥夺中拯救出来并刺激神经发生和突触发生^[2]。

The ED₅₀ is <10 ng/mL as measured by FDCP-1 cells, corresponding to a specific activity of >1.0 × 10⁵ units/mg.

Rat

E. coli

Tag Free

P08025 (G49-A118)

24482  [NCBI]

MGPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPTKSA

Approximately 7.8 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized after extensive dialysis against PBS.

<0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Schoenle E, et al. Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature. 1982 Mar 18;296(5854):252-3.  [Content Brief]

  [2]. Thorne RG, et al. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience. 2004;127(2):481-96.  [Content Brief]