2. 重组蛋白
  3. Cytokines and Growth Factors
  4. IGF family
  5. Insulin-like Growth Factor I (IGF-1)

Insulin-like Growth Factor I (IGF-1)  (胰岛素样生长因子 1)

重组蛋白定制服务

胰岛素样生长因子 (IGFs) 是一种组织生长因子，也是一种循环激素。它们积极参与哺乳动物的发育和生长。IGF 家族有两种配体，IGF-I和IGF-II，它们与胰岛素结构相似。IGF-I和IGF-II是单链多肽，在进化上保守。这两个分子的氨基酸序列有 62% 的同源性。IGFs 需要一个复杂的系统，通常它被称为 IGF “轴”系统，应包括 IGF-I 和 IGF-II，对每种 IGFs具有特异性的，具有酪氨酸激酶活性的两个细胞表面受体 IGF-1R 和 IGF-2R，和一个 IGF结合蛋白 (IGFBPs) 家族。IGFs 在调节细胞增殖、分化、凋亡和转化中发挥重要作用。

Insulin-like growth factors (IGFs) function as both tissue growth factors and circulating hormones. They actively participate in mammalian development and growth. The IGF family is comprised of insulin and two factors similar to insulin termed IGF-1 and IGF-2. IGF-I and IGF-II are single-chain polypeptides and evolutionarily conserved. The two molecules have 62% homology in their amino acid sequences and their structures resemble the structure of proinsulin. IGFs need a complex system to act, often, it is known as the IGF “axis” system, which should include two IGFs type as IGF-I and IGF-II, two cell-surface receptors such as IGF-receptor type 1 (IGF-1R) and IGF-receptor type 2 (IGF-2R), specific to each IGFs type with tyrosine kinase activity and a family of IGF binding proteins (IGFBPs) . IGFs play an important role in regulating cell proliferation, differentiation, apoptosis, and transformation.

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