1. 重组蛋白
  2. Cytokines and Growth Factors
  3. IGF family
  4. IGFBP-2
  5. IGF2BP2 蛋白, Human (T7-His)

IGF2BP2 蛋白, Human (T7-His)

目录号: HY-P70950
COA 产品使用指南

IGF2BP2 蛋白是一种 RNA 结合因子,可协调靶转录本招募到细胞质 mRNP 中,促进 mRNA 运输和瞬时储存。它调节目标转录本与翻译机制的接触,并保护它们免受 microRNA 介导的降解。IGF2BP2 蛋白, Human (T7-His) 是重组的 IGF2BP2 蛋白,由 E. coli 表达,带有 N-T7, C-6*His 标签。IGF2BP2 蛋白, Human (T7-His) 全长 220 个氨基酸,分子量约为 ~43.0 kDa。

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10 μg ¥1700 In-stock
50 μg ¥5100 In-stock
100 μg   询价  

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描述

The IGF2BP2 protein is an RNA-binding factor that coordinates the recruitment of target transcripts into cytoplasmic mRNP, promoting mRNA transport and transient storage. It regulates the contact of target transcripts with the translation machinery and protects them from microRNA-mediated degradation. IGF2BP2 Protein, Human (T7-His) is the recombinant human-derived IGF2BP2 protein, expressed by E. coli , with N-T7, C-6*His labeled tag. The total length of IGF2BP2 Protein, Human (T7-His) is 220 a.a., with molecular weight of ~43.0 kDa.

研究背景

IGF2BP2 蛋白充当 RNA 结合因子,协调靶转录物招募到细胞质蛋白-RNA 复合物 (mRNP) 中。mRNP 内转录本的这种“囚禁”有利于 mRNA 运输和瞬时存储,同时调节目标转录本遇到翻译装置的速率和位置。此外,IGF2BP2 保护这些转录物免受核酸内切酶攻击或 microRNA 介导的降解。由于偏爱含有 N6-甲基腺苷 (m6A) 的 mRNA,IGF2BP2 增强了它们的稳定性。它与胰岛素样生长因子 2 (IGF2) mRNA 的 5'-UTR 特异性结合,并选择性地与 β-肌动蛋白/ACTB 和 MYC 等转录物结合,通过与编码区不稳定决定簇 (CRD) 相互作用提高 MYC mRNA 稳定性。IGF2BP2 可以以 RNA 依赖性方式与 IGF2BP1 和 IGF2BP3 形成同寡聚体和异寡聚体,并与多种蛋白质相互作用,包括 HNRPD、IGF2BP1、ELAVL1、DHX9、HNRNPU、MATR3 和 PABPC1。它与 HOXB-AS3 肽的相互作用进一步增强了 MYC 稳定性。

种属

Human

表达系统

E. coli

标签

N-T7;C-6*His

蛋白编号

Q9Y6M1 (M1-T220)

基因 ID
蛋白结构
N-term
T7
IGF2BP2 (M1-T220)
Accession # Q9Y6M1
6*His
C-term
同用名
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2; IGF2 mRNA-Binding Protein 2; IMP-2; Hepatocellular Carcinoma Autoantigen p62; IGF-II mRNA-Binding Protein 2; VICKZ Family Member 2; IGF2BP2; IMP2; VICKZ2
氨基酸序列

MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTETAVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNIT

分子量

Approximately 43.0 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料

IGF2BP2 Protein, Human (T7-His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IGF2BP2 Protein, Human (T7-His)
目录号:
HY-P70950
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