IgG1 蛋白, Mouse (HEK293, C102S)

IgG1 Protein is the most abundant Immunoglobulin G (IgG) subclass in human sera and is important for mediating antibody responses against viral pathogens. IgG1 enables antigen binding activity and immunoglobulin receptor binding activity. It acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity, phagocytosis, and positive regulation of immune response. IgG1 Protein, Mouse (HEK293, C102S) is the recombinant mouse-derived IgG1 protein, expressed by HEK293 , with tag free. The total length of IgG1 Protein, Mouse (HEK293, C102S) is 227 a.a., with molecular weight of ~32 kDa.

Ig gamma-1 链 C 区分泌型 (IgG1) 是人血清中最丰富的免疫球蛋白 G (IgG) 亚类，对于介导针对病毒病原体的抗体反应非常重要。它通过其可变结构域与可溶性蛋白和膜蛋白抗原结合并同时激活先天免疫系统的效应机制来实现这一点。IgG1 具有抗原结合活性和免疫球蛋白受体结合活性。它在多个过程的上游或内部发挥作用，包括抗体依赖性细胞毒性、吞噬作用和免疫反应的正向调节。IgG1 可以有效地与 C1q 结合，导致补体依赖性细胞毒性 (CDC)，并且可以与每种不同的 Fc 受体结合，从而导致抗体依赖性细胞介导的细胞毒性 (ADCC)^[1]。

Mouse

HEK293

Tag Free

P01868 (V98-K324, C102S)

16017  [NCBI]

Approximately 32 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.