2. 重组蛋白
  3. Fc Receptors
  4. Immunoglobulin Fc Region
  5. IgG2
  6. IgG2 Fc 蛋白, Human (228a.a, V161M, S257A, HEK293)

IgG2 Fc 蛋白, Human (228a.a, V161M, S257A, HEK293)

目录号: HY-P72605
产品使用指南

IgG2 Fc 蛋白是免疫球蛋白重链的恒定区，充当抗原受体，触发 B 淋巴细胞扩增并分化为分泌免疫球蛋白的浆细胞。IgG2 Fc 蛋白, Human (228a.a, V161M, S257A, HEK293) 是重组的 IgG2 Fc 蛋白，由 HEK293 表达，不带标签。IgG2 Fc 蛋白, Human (228a.a, V161M, S257A, HEK293) 全长 228 个氨基酸，分子量约为 ~32 kDa。

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规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

The IgG2 Fc protein is the constant region of the immunoglobulin heavy chain and acts as an antigen receptor, triggering the expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. IgG2 Fc Protein, Human (228a.a, V161M, S257A, HEK293) is the recombinant human-derived IgG2 Fc protein, expressed by HEK293 , with tag free. The total length of IgG2 Fc Protein, Human (228a.a, V161M, S257A, HEK293) is 228 a.a., with molecular weight of ~32 kDa.
研究背景

免疫球蛋白重链的恒定区（称为抗体）包含由 B 淋巴细胞合成的膜结合或分泌糖蛋白。在体液免疫的识别阶段，这些膜结合的免疫球蛋白充当受体，在结合特定抗原后触发B淋巴细胞的克隆扩增和分化为分泌免疫球蛋白的浆细胞。由分泌的免疫球蛋白介导的效应阶段导致结合抗原的消除。抗原结合位点由一条重链的可变结构域及其相关轻链的可变结构域形成，导致每种免疫球蛋白拥有两个对特定抗原具有显着亲和力的抗原结合位点。可变结构域经历 V-(D)-J 重排和随后的体细胞超突变，促进暴露和选择后特定抗原的亲和力成熟。免疫球蛋白由两条相同的重链和两条相同的轻链组成，通过二硫键互连。
种属

Human
表达系统

HEK293
标签

Tag Free
蛋白编号

P01859 (E99-K326, V161M, S257A)
基因 ID
蛋白结构
N-term
IgG2 Fc (E99-K326, V161M, S257A)
Accession # P01859
C-term
同用名
Immunoglobulin heavy constant gamma 2; IGHG2; Ig gamma-2 chain C region; IgG2 Fc
氨基酸序列

ERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGMEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

分子量

Approximately 32 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

IgG2 Fc Protein, Human (228a.a, V161M, S257A, HEK293) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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