Integrin alpha X beta 2 蛋白, Human (HEK293, Flag-His)

Integrin alpha-X/beta-2, a receptor for fibrinogen, crucially recognizes the G-P-R sequence. It plays a pivotal role in inflammatory responses, especially in monocyte adhesion and chemotaxis. Structurally, forming a heterodimer, the alpha-X subunit associates with the beta-2 subunit. This receptor's fibrinogen recognition underscores its significance in immune responses, emphasizing its role in regulating monocyte functions and cell migration during inflammation. Integrin alpha X beta 2 Protein, Human (HEK293, Flag-His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein, expressed by HEK293, with C-His, C-Flag labeled tag. Integrin alpha X beta 2 Protein, Human (HEK293, Flag-His), has molecular weight of ~95 & 130 kDa, respectively.

整合素 α-X/β-2 蛋白作为纤维蛋白原的受体，识别其配体中的 GPR 序列。整合素 α-X/β-2 对于炎症反应期间的细胞间相互作用至关重要，在单核细胞粘附和趋化性中发挥着特别重要的作用。在结构上，它形成异二聚体，由 α 和 β 亚基组成，其中 α-X 亚基与 β-2 亚基结合。该受体对纤维蛋白原的识别及其参与炎症过程强调了其在促进免疫反应中的重要性，强调了其在炎症过程中调节单核细胞功能和细胞迁移的作用。

Human

HEK293

C-His;C-Flag

P20702 (P20-P1107)&P05107 (Q23-N700)

3687  [NCBI]&3689  [NCBI]

Approximately 95&130 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.