2. 重组蛋白
  3. Enzymes & Regulators
  4. Hydrolases (EC 3)
  5. Kallikrein-1 蛋白, Mouse (HEK293, His)

Kallikrein-1 蛋白, Mouse (HEK293, His)

目录号: HY-P70302
产品使用指南

Kallikrein-1 蛋白是腺激肽释放酶家族的一员，通过裂解激肽原中的 Met-Lys 和 Arg-Ser 键释放 Lys-缓激肽，在酶活性中发挥重要作用。。这种蛋白水解对于缓激肽的产生至关重要，缓激肽是一种参与多种生理过程的生物活性肽，包括血压调节、炎症和血管通透性。Kallikrein-1 蛋白, Mouse (HEK293, His) 是重组的 Kallikrein-1 蛋白，由 HEK293 表达，带有 C-6*His 标签。Kallikrein-1 蛋白, Mouse (HEK293, His) 全长 243 个氨基酸，分子量为 34-38 kDa。

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规格 是否有货
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描述

Kallikrein-1 protein is a member of the glandular kallikrein family and plays a vital role in enzyme activity by cleaving the Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. . This proteolysis is critical for the production of bradykinin, a bioactive peptide involved in multiple physiological processes, including blood pressure regulation, inflammation, and vascular permeability. Kallikrein-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Kallikrein-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Kallikrein-1 Protein, Mouse (HEK293, His) is 243 a.a., with molecular weight of 34-38 kDa.
研究背景

Kallikrein-1 是一种属于腺激肽释放酶家族的蛋白质，它通过裂解激肽原中的 Met-Lys 和 Arg-Ser 键而表现出蛋白水解活性，导致 Lys-缓激肽的释放。这种酶活性使激肽释放酶-1 成为激肽-激肽释放酶系统中的关键角色，激肽-激肽释放酶系统是一个涉及血压、炎症和血管通透性调节的复杂途径。通过生成赖氨酸缓激肽，Kallikrein-1 有助于缓激肽的产生，缓激肽是一种具有多种生理作用的有效血管活性肽。
种属

Mouse
表达系统

HEK293
标签

C-6*His
蛋白编号

P15947 (P19-D261)
基因 ID

16612  [NCBI]
蛋白结构
N-term
Kallikrein-1 (P19-D261)
Accession # P15947
6*His
C-term
同用名
rMuKallikrein-1, His ; Glandular kallikrein K1; KAL-B; Renal kallikrein; Tissue kallikrein-6; mGK-6
氨基酸序列

PPVQSRIVGGFNCEKNSQPWQVAVYRFTKYQCGGILLNANWVLTAAHCHNDKYQVWLGKNNFLEDEPSAQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLKKPADITDVVKPIDLPTEEPKLGSTCLASGWGSITPVKYEYPDELQCVNLKLLPNEDCAKAHIEKVTDDMLCAGDMDGGKDTCAGDSGGPLICDGVLQGITSWGPSPCGKPNVPGIYTRVLNFNTWIRETMAEND

分子量

34-38 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Kallikrein-1 Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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