1. 重组蛋白
  2. Receptor Proteins
  3. Killer-Cell Immunoglobulin-like Receptors
  4. CD158b2/KIR2DL3
  5. KIR2DL3 蛋白, Human (HEK293, His)

KIR2DL3 蛋白, Human (HEK293, His)

目录号: HY-P70354
产品使用指南

KIR2DL3 存在于 NK 细胞上,选择性识别 HLA-C 等位基因,如 HLA-Cw1、HLA-Cw3 和 HLA-Cw7。它的相互作用会产生抑制作用,阻止 NK 细胞活性和细胞裂解。KIR2DL3 与 ARRB2 的关联强调了其在细胞信号通路中的作用,复杂地调节 NK 细胞功能。KIR2DL3 蛋白, Human (HEK293, His) 是重组的 KIR2DL3 蛋白,由 HEK293 表达,带有 C-6*His 标签。KIR2DL3 蛋白, Human (HEK293, His) 全长 224 个氨基酸,分子量为 35-50 kDa。

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描述

KIR2DL3, found on NK cells, selectively recognizes HLA-C alleles like HLA-Cw1, HLA-Cw3, and HLA-Cw7. Its interaction leads to inhibitory effects, preventing NK cell activity and cell lysis. KIR2DL3's association with ARRB2 underscores its role in cellular signaling pathways, intricately modulating NK cell functions. KIR2DL3 Protein, Human (HEK293, His) is the recombinant human-derived KIR2DL3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of KIR2DL3 Protein, Human (HEK293, His) is 224 a.a., with molecular weight of 35-50 kDa.

研究背景

KIR2DL3 在自然杀伤 (NK) 细胞上表达,作为特异性识别 HLA-C 等位基因(例如 HLA-Cw1、HLA-Cw3 和 HLA-Cw7)的受体发挥作用。通过这种相互作用,KIR2DL3 对 NK 细胞活性产生抑制作用,在防止细胞裂解方面发挥着至关重要的作用。该受体进一步与 ARRB2 结合,突显其参与调节 NK 细胞功能的复杂细胞信号传导途径。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

P43628 (H22-H245)

基因 ID
蛋白结构
N-term
KIR2DL3 (H22-H245)
Accession # P43628
6*His
C-term
同用名
rHuKiller cell immunoglobulin-like receptor 2DL3/KIR2DL3, His; Killer Cell Immunoglobulin-Like Receptor 2DL3; CD158 Antigen-Like Family Member B2; KIR-023GB; Killer Inhibitory Receptor cl 2-3; MHC Class I NK Cell Receptor; NKAT2a; NKAT2b; Natural Killer-Associated Transcript 2; NKAT-2; p58 Natural Killer Cell Receptor Clone C
氨基酸序列

HEGVHRKPSLLAHPGPLVKSEETVILQCWSDVRFQHFLLHREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSETGNPRHLH

分子量

35-50 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

KIR2DL3 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
KIR2DL3 Protein, Human (HEK293, His)
目录号:
HY-P70354
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