1. 重组蛋白
  2. Receptor Proteins
  3. Killer-Cell Immunoglobulin-like Receptors
  4. KIR2DS3
  5. KIR2DS3 蛋白, Human (P.pastoris, His)

KIR2DS3 蛋白, Human (P.pastoris, His)

目录号: HY-P71815
产品使用指南

KIR2DS3 存在于 NK 细胞上,选择性识别 HLA-C 等位基因。与抑制性 KIR 相比,KIR2DS3 对 NK 细胞活性缺乏抑制作用。它的作用可能是激活或调节 NK 细胞功能,有助于调节免疫反应的信号的微妙平衡。KIR2DS3 蛋白, Human (P.pastoris, His) 是重组的 KIR2DS3 蛋白,由 P. pastoris 表达,带有 N-His 标签。KIR2DS3 蛋白, Human (P.pastoris, His) 全长 224 个氨基酸,分子量约为 ~26.7 kDa。

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描述

KIR2DS3, present on NK cells, selectively recognizes HLA-C alleles. In contrast to inhibitory KIRs, KIR2DS3 lacks inhibitory effects on NK cell activity. Its role is likely in activating or modulating NK cell functions, contributing to the nuanced balance of signals regulating the immune response. KIR2DS3 Protein, Human (P.pastoris, His) is the recombinant human-derived KIR2DS3 protein, expressed by P. pastoris , with N-His labeled tag. The total length of KIR2DS3 Protein, Human (P.pastoris, His) is 224 a.a., with molecular weight of ~26.7 kDa.

研究背景

KIR2DS3 在自然杀伤 (NK) 细胞上表达,作为特异性识别 HLA-C 等位基因的受体。与抑制性 KIR 相比,KIR2DS3 不会对 NK 细胞活性产生抑制作用。相反,它可能在激活或调节 NK 细胞功能中发挥作用,有助于调节免疫反应的信号的复杂平衡。

种属

Human

表达系统

P. pastoris

标签

N-His

蛋白编号

Q14952 (22H-245H)

基因 ID

3808  [NCBI]

蛋白结构
N-term
His
KIR2DS3 (22H-245H)
Accession # Q14952
C-term
同用名
KIR2DS3; NKAT7Killer cell immunoglobulin-like receptor 2DS3; MHC class I NK cell receptor; Natural killer-associated transcript 7; NKAT-7
氨基酸序列

HEGFRRKPSLLAHPGRLVKSEETVILQCWSDVMFEHFLLHREGTFNDTLRLIGEHIDGVSKANFSIGRMRQDLAGTYRCYGSVPHSPYQFSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSWSSYDMYHLSTEGEAHERRFSAGPKVNGTFQADFPLGPATQGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLH

分子量

Approximately 26.7 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

KIR2DS3 Protein, Human (P.pastoris, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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KIR2DS3 Protein, Human (P.pastoris, His)
目录号:
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