LAP3 蛋白, Human (HEK293, His)

The LAP3 protein is a cytosolic metallopeptidase that serves as a catalytic entity responsible for the removal of unsubstituted N-terminal hydrophobic amino acids from a variety of peptides. The peptidase activity of LAP3 depends on the presence of Zn(2+) ions, and its substrate specificity can be modulated by binding to other cofactors. LAP3 Protein, Human (HEK293, His) is the recombinant human-derived LAP3 protein, expressed by HEK293 , with C-His labeled tag. The total length of LAP3 Protein, Human (HEK293, His) is 519 a.a., with molecular weight of ~57.6 kDa.

亮氨酸氨基肽酶 3 (LAP3) 是一种胞质金属肽酶，对于催化从各种肽中去除未取代的 N 末端疏水性氨基酸至关重要。LAP3 的酶活性取决于 Zn(2+) 离子的存在，并且与其他辅助因子的结合可以调节其底物特异性。在 Mn(2+) 存在下，LAP3 表现出特定的 Cys-Gly 水解活性，针对 Cys-Gly-S-缀合物。这种肽酶主要参与谷胱甘肽的代谢和谷胱甘肽 S-缀合物的降解，表明其在调节细胞氧化还原状态中发挥作用。多种底物特异性和参与细胞过程强调了 LAP3 在肽代谢和细胞氧化还原控制中的重要性。

Human

HEK293

C-His

P28838/NP_056991.2 (M1-A519)

51056  [NCBI]

Approximately 57.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.