2. 重组蛋白
  3. Receptor Proteins
  4. LDLR 蛋白, Human (Biotinylated, HEK293, Avi-His)

LDLR 蛋白, Human (Biotinylated, HEK293, Avi-His)

目录号: HY-P72392
产品使用指南

LDLR 蛋白在胆固醇稳态中发挥着关键作用，与 LDL 结合并通过内吞作用介导细胞摄取。聚集成网格蛋白包被的小坑对于内化至关重要。在微生物感染中，LDLR 作为肝细胞中丙型肝炎病毒的受体，强调其在胆固醇代谢和对病毒感染的细胞反应中的双重功能。LDLR 蛋白, Human (Biotinylated, HEK293, Avi-His) 是重组的 LDLR 蛋白，由 HEK293 表达，带有 C-Avi, C-6*His 标签。LDLR 蛋白, Human (Biotinylated, HEK293, Avi-His) 全长 767 个氨基酸，分子量为 95-140 kDa。

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描述

LDLR Protein plays a pivotal role in cholesterol homeostasis, binding to LDL and mediating cellular uptake through endocytosis. Clustering into clathrin-coated pits is essential for internalization. In microbial infection, LDLR acts as a receptor for hepatitis C virus in hepatocytes, emphasizing its dual functionality in cholesterol metabolism and the cellular response to viral infections. LDLR Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived LDLR protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of LDLR Protein, Human (Biotinylated, HEK293, Avi-His) is 767 a.a., with molecular weight of 95-140 kDa.
研究背景

LDLR 蛋白通过与低密度脂蛋白 (LDL)（血浆中主要携带胆固醇的脂蛋白）结合，并通过内吞作用促进其细胞摄取，从而成为胆固醇稳态的重要介质。为了实现内化，受体-配体复合物必须首先聚集成网格蛋白包被的凹坑。此外，在微生物感染的情况下，LDLR 作为肝细胞内丙型肝炎病毒的受体，尽管这种相互作用不是通过与病毒蛋白直接结合而发生的。这种双重功能强调了 LDLR 在胆固醇代谢和病毒感染细胞反应中的不同作用。
种属

Human
表达系统

HEK293
标签

C-Avi;C-6*His
蛋白编号

P01130 (A22-R788)
基因 ID
蛋白结构
N-term
LDLR (A22-R788)
Accession # P01130
Avi-6*His
C-term
同用名
Low-Density Lipoprotein Receptor; LDL Receptor; LDLR
氨基酸序列

AVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVR

分子量

95-140 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

LDLR Protein, Human (Biotinylated, HEK293, Avi-His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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