LDLR 蛋白, Human (HEK293)

LDLR Protein plays a pivotal role in cholesterol homeostasis, binding to LDL and mediating cellular uptake through endocytosis. Clustering into clathrin-coated pits is essential for internalization. In microbial infection, LDLR acts as a receptor for hepatitis C virus in hepatocytes, emphasizing its dual functionality in cholesterol metabolism and the cellular response to viral infections. LDLR Protein, Human (HEK293) is the recombinant human-derived LDLR protein, expressed by HEK293, with tag free.

LDLR 蛋白通过与低密度脂蛋白 (LDL)（血浆中主要携带胆固醇的脂蛋白）结合，并通过内吞作用促进其细胞摄取，从而成为胆固醇稳态的重要介质。为了实现内化，受体-配体复合物必须首先聚集成网格蛋白包被的凹坑。此外，在微生物感染的情况下，LDLR 作为肝细胞内丙型肝炎病毒的受体，尽管这种相互作用不是通过与病毒蛋白直接结合而发生的。这种双重功能强调了 LDLR 在胆固醇代谢和病毒感染细胞反应中的不同作用。

Human

HEK293

Tag Free

P01130-1 (A22-R788)

3949

Approximately 80-90 kDa and 110-120 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from 0.22 μm filtered solution of PBS, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.