1. 重组蛋白
  2. Receptor Proteins
  3. Leptin R/LEPR 蛋白, Mouse (HEK293, His)

Leptin R/LEPR 蛋白, Mouse (HEK293, His)

目录号: HY-P72523
COA 产品使用指南

瘦素R/LEPR蛋白作为激素LEP/瘦素的受体,通过激活各种信号通路(如JAK2/STAT3和MAPK级联/FOS)介导中枢和外周效应。在下丘脑中,它调节食欲、能量消耗、骨量和激素分泌。Leptin R/LEPR 蛋白, Mouse (HEK293, His) 是重组的 瘦素 R/LEPR 蛋白,由 HEK293 表达,带有 C-10*His 标签。Leptin R/LEPR 蛋白, Mouse (HEK293, His) 全长 818 个氨基酸,分子量为 120-150 kDa。

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10 μg ¥1100 In-stock
50 μg ¥3100 In-stock
100 μg   询价  

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描述

Leptin R/LEPR protein, as a receptor for the hormone LEP/leptin, mediates central and peripheral effects by activating various signaling pathways (such as JAK2/STAT3 and MAPK cascade/FOS). In the hypothalamus, it regulates appetite, energy expenditure, bone mass, and hormone secretion. Leptin R/LEPR Protein, Mouse (HEK293, His) is the recombinant mouse-derived Leptin R/LEPR protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Leptin R/LEPR Protein, Mouse (HEK293, His) is 818 a.a., with molecular weight of 120-150 kDa.

研究背景

瘦素 R/LEPR 是激素 LEP/瘦素的受体,通过激活不同的信号通路(包括 JAK2/STAT3 和 MAPK 级联/FOS),在介导瘦素的中枢和外周效应中发挥关键作用。在下丘脑中,瘦素作为食欲调节因子,诱导食物摄入减少和能量消耗增加,从而调节骨量和下丘脑-垂体-肾上腺激素。在外周,瘦素 R/LEPR 影响基础代谢、生殖功能、胰腺 β 细胞功能、胰岛素分泌、血管生成和免疫反应。它通过 STAT3 信号传导控制能量稳态和黑皮质素的产生,调节各种生理过程,如生育、生长和葡萄糖稳态。此外,瘦素 R/LEPR 参与低血糖的反调节反应,并对 T 淋巴细胞反应产生特定影响,影响细胞因子的产生和 T 细胞增殖。它还可能在运输瘦素穿过血脑屏障并介导其内吞作用而不诱导 STAT3 磷酸化方面发挥作用。

种属

Mouse

表达系统

HEK293

标签

C-10*His

蛋白编号

P48356 (L22-G839)

基因 ID

16847  [NCBI]

蛋白结构
N-term
LEPR (L22-G839)
Accession # P48356
10*His
C-term
同用名
Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; LEPR; DB; OBR
氨基酸序列

LNLAYPISPWKFKLFCGPPNTTDDSFLSPAGAPNNASALKGASEAIVEAKFNSSGIYVPELSKTVFHCCFGNEQGQNCSALTDNTEGKTLASVVKASVFRQLGVNWDIECWMKGDLTLFICHMEPLPKNPFKNYDSKVHLLYDLPEVIDDSPLPPLKDSFQTVQCNCSLRGCECHVPVPRAKLNYALLMYLEITSAGVSFQSPLMSLQPMLVVKPDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSSPQVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVSDRVSKVTFSNLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHPTSEPKNCVLQRDGFYECVFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITVNTGLLKVSWEKPVFPENNLQFQIRYGLSGKEIQWKTHEVFDAKSKSASLLVSDLCAVYVVQVRCRRLDGLGYWSNWSSPAYTLVMDVKVPMRGPEFWRKMDGDVTKKERNVTLLWKPLTKNDSLCSVRRYVVKHRTAHNGTWSEDVGNRTNLTFLWTEPAHTVTVLAVNSLGASLVNFNLTFSWPMSKVSAVESLSAYPLSSSCVILSWTLSPDDYSLLYLVIEWKILNEDDGMKWLRIPSNVKKFYIHDNFIPIEKYQFSLYPVFMEGVGKPKIINGFTKDAIDKQQNDAG

分子量

120-150 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

Leptin R/LEPR Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Leptin R/LEPR Protein, Mouse (HEK293, His)
目录号:
HY-P72523
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