LGP2 蛋白, Human (HEK293, His, Strep, FLAG)

LGP2 protein is a key regulator of RIGI- and IFIH1/MDA5-mediated antiviral signaling and has dual negative and positive functions affected by factors such as infected viruses and target cells. LGP2 lacks a CARD domain for independent initiation of antiviral signaling and therefore inhibits RIG-I through multiple mechanisms, including competition for RNA binding and obstruction of interaction with MAVS/IPS1. LGP2 Protein, Human (HEK293, His, Strep, FLAG) is the recombinant human-derived LGP2 protein, expressed by HEK293 , with N-Strep, C-Flag, N-8*His labeled tag. The total length of LGP2 Protein, Human (HEK293, His, Strep, FLAG) is 678 a.a., .

LGP2 蛋白作为 RIGI 和 IFIH1/MDA5 介导的抗病毒信号传导的关键调节因子，发挥负调节功能和正调节功能，这些功能取决于多种因素，例如感染病毒、靶细胞或两者的组合。由于缺乏激活 MAVS/IPS1 依赖性信号传导事件所需的 CARD 结构域，LGP2 无法自行启动抗病毒信号传导。其对RIG-I信号传导的抑制作用可能涉及多种机制，包括与RIGI竞争与病毒RNA的结合、直接与RIGI结合以阻止二聚化和与MAVS/IPS1的相互作用、与IKBKE竞争与MAVS/IPS1的结合，从而阻碍IRF3 激活。相反，其正向调节作用可能包括从病毒 RNA 中解旋或剥离核蛋白等活动，从而促进 RIGI 和 IFIH1/MDA5 的识别。LGP2 在针对各种 RNA 病毒、DNA 病毒（如痘病毒和冠状病毒 SARS-CoV-2）以及细菌病原体单核细胞增生李斯特菌的先天免疫反应中发挥着至关重要的作用，突显了其在抗病毒防御中的多功能参与。该蛋白质对单链和双链 RNA 均表现出亲和力，并且优先选择 5'-三磷酸化 RNA，尽管它可以识别缺乏这种修饰的 RNA。

Human

HEK293

N-Strep;C-Flag;N-8*His

Q96C10 (M1-D678)

79132

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.