1. 重组蛋白
  2. CD Antigens Receptor Proteins
  3. NK Cell CD Proteins Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Leukocyte Immunoglobin-like Receptors
  4. CD85j/LIR-1 LIR-1
  5. LILRB1/CD85j/ILT2 蛋白, Human (HEK293, Fc)

LILRB1/CD85j/ILT2 蛋白, Human (HEK293, Fc)

目录号: HY-P70182
产品使用指南

LILRB1/CD85j/ILT2 蛋白是一种在白细胞上广泛表达的抑制性受体。LILRB1 通过与保守的 a3 结构域结合,识别多种经典 HLA-I 类等位基因变体,以及非经典分子 HLA-F 和 -G。LILRB1 还识别人类 CMV 编码的 MHC I 类同源物 UL18。LILRB1 在 19q13.4 上的白细胞受体复合物内编码。LILRB1 可以作为 BiTE 分子诱导的肿瘤细胞杀伤的负调节因子。LILRB1 作为一种新型检查点抑制分子,能够限制 BiTE 分子介导的 CD8+ T 细胞效应功能。LILRB1/CD85j/ILT2 蛋白, Human (HEK293, Fc) 是重组的 LILRB1/CD85j/ILT2 蛋白,由 HEK293 表达,带有 C-hFc 标签。LILRB1/CD85j/ILT2 蛋白, Human (HEK293, Fc) 全长 435 个氨基酸,分子量为 100-120 kDa。

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描述

LILRB1/CD85j/ILT2 Protein is an inhibitory receptor broadly expressed on leukocytes. LILRB1 recognises a wide range of classical HLA-class I allelic variants, as well as the non-classical molecules HLA-F and -G by binding to the conserved a3 domain. LILRB1 also recognises the human CMV-encoded MHC class I homologue UL18. LILRB1 is encoded within the leukocyte receptor complex on 19q13.4. LILRB1 can function as a negative regulator of BiTE molecule-induced tumor cell killing. LILRB1 acts as a novel checkpoint inhibitory molecule capable of restricting BiTE molecule-mediated CD8+ T cell effector function[1][2][3][4]. LILRB1/CD85j/ILT2 Protein, Human (HEK293, Fc) is the recombinant human-derived LILRB1/CD85j/ILT2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LILRB1/CD85j/ILT2 Protein, Human (HEK293, Fc) is 435 a.a., with molecular weight of 100-120 kDa.

研究背景

LILRB1 结合 MHC I 类,还含有基于免疫受体酪氨酸的抑制基序,参与细胞内抑制信号转导,这使它们成为 MHC I 类介导的吞噬作用抑制的有力候选者[1]
LILRB1 和 PD1 在 CD8+ TEM 和 TEMRA 亚群中显示出不重叠的表达模式,并且阻断这两种途径可协同增强 CD8+ T 细胞功能。LILRB1 由 CD8+ TEMRA 子集高度表达,这是 BiTE 分子诱导毒性最有效的群体。表达 LILRB1 的 CD8+ T 细胞浸润实体瘤。LILRB1 阻断可增加体外 CD8+ T 细胞的溶细胞活性[3]

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

D9IDM8 (G24-H458)

基因 ID

10859

蛋白结构
N-term
LILRB1 (G24-H458)
Accession # D9IDM8
hFc
C-term
同用名
rHuLIR-1/LILRB1, Fc; Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1; LIR-1; Leukocyte Immunoglobulin-Like Receptor 1; CD85 Antigen-Like Family Member J; Immunoglobulin-Like Transcript 2; ILT-2; Monocyte/Macrophage Immunoglobulin-Like Receptor 7; MIR-7; CD85j; LILRB1; ILT2; LIR1; MIR7
氨基酸序列

GHLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRLYREKKTAPWITRIPQELVKKGQFPIPSITWEHAGRYRCYYGSDTAGRSESSDPLELVVTGAYIKPTLSAQPSPVVNSGGNVTLQCDSQVAFDGFILCKEGEDEHPQCLNSQPHARGSSRAIFSVGPVSPSRRWWYRCYAYDSNSPYEWSLPSDLLELLVLGVSKKPSLSVQPGPIVAPEETLTLQCGSDAGYNRFVLYKDGERDFLQLAGAQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSEWSAPSDPLDILIAGQFYDRVSLSVQPGPTVASGENVTLLCQSQGWMQTFLLTKEGAADDPWRLRSTYQSQKYQAEFPMGPVTSAHAGTYRCYGSQSSKPYLLTHPSDPLELVVSGPSGGPSSPTTGPTSTSGPEDQPLTPTGSDPQSGLGRH

分子量

100-120 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
LILRB1/CD85j/ILT2 Protein, Human (HEK293, Fc)
目录号:
HY-P70182
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