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  3. LRRTM4 蛋白, Human (HEK293, His)

LRRTM4 蛋白, Human (HEK293, His)

目录号: HY-P76481
产品使用指南

LRRTM4 蛋白在脊椎动物神经系统的发育和维持中发挥着关键作用,特别是在突触发生和兴奋性突触前元件的分化中。LRRTM4与AMPA受体(AMPAR)复合物相关,位于复合物的外围,直接与GluA/GRIA蛋白相互作用,有助于协调AMPAR复合物组装和功能的复杂网络。LRRTM4 蛋白, Human (HEK293, His) 是重组的 LRRTM4 蛋白,由 HEK293 表达,带有 C-His 标签。LRRTM4 蛋白, Human (HEK293, His) 全长 394 个氨基酸,分子量约为 ~65 KDa。

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描述

The LRRTM4 protein plays a critical role in the development and maintenance of the vertebrate nervous system, particularly in synaptogenesis and differentiation of excitatory presynaptic elements. LRRTM4 is associated with the AMPA receptor (AMPAR) complex, is located at the periphery of the complex, interacts directly with GluA/GRIA proteins, and helps coordinate the complex network of AMPAR complex assembly and function. LRRTM4 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRRTM4 Protein, Human (HEK293, His) is 394 a.a., with molecular weight of ~65 KDa.

研究背景

LRRTM4 蛋白在脊椎动物神经系统的发育和维持中发挥着关键作用,在突触发生中发挥着特别显着的作用,特别是影响兴奋性突触前分化。LRRTM4 在功能上与 AMPA 受体 (AMPAR) 复合物相关,位于该复合物的外围,该复合物由一个内核组成,该内核包含四个成孔 GluA/GRIA 蛋白和四个主要辅助亚基。LRRTM4 是外核的一部分,直接与 GluA/GRIA 蛋白相互作用,并有助于协调 AMPAR 复合物组装和功能的复杂蛋白质网络。了解 LRRTM4 在兴奋性神经传递和 AMPAR 复合体动力学调节中的作用有望揭示神经系统中突触连接的复杂性。需要进一步研究来阐明 LRRTM4 影响兴奋性突触前分化并促进整体神经网络发育的具体机制。

种属

Human

表达系统

HEK293

标签

C-His

蛋白编号

Q86VH4 (Q31-K424)

基因 ID
蛋白结构
N-term
LRRTM4 (Q31-K424)
Accession # Q86VH4
His
C-term
同用名
Leucine-rich repeat transmembrane neuronal protein 4
分子量

Approximately 65 kDa.

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

LRRTM4 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
LRRTM4 Protein, Human (HEK293, His)
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HY-P76481
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