1. 重组蛋白
  2. Enzymes & Regulators
  3. Matrix Metalloproteinases
  4. MMP-8
  5. MMP-8 蛋白, Human (HEK293, His)

MMP-8 蛋白, Human (HEK293, His)

目录号: HY-P72507
COA 产品使用指南

MMP-8,也称为基质金属蛋白酶-8 或胶原酶-2,因其酶促能力而闻名,特别是其分解纤维状 I、II 和 III 型胶原蛋白的能力。这种酶活性表明 MMP-8 在富含胶原蛋白的组织(如结缔组织、软骨和骨)的重塑和周转中发挥着重要作用。MMP-8 蛋白, Human (HEK293, His) 是重组的 MMP-8 蛋白,由 HEK293 表达,带有 C-10*His 标签。MMP-8 蛋白, Human (HEK293, His) 全长 447 个氨基酸,分子量约为 approximately 64.09 kDa。

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描述

MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Human (HEK293, His) is the recombinant human-derived MMP-8 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MMP-8 Protein, Human (HEK293, His) is 447 a.a., with molecular weight of approximately 64.09 kDa.

研究背景

MMP-8,也称为基质金属蛋白酶-8 或胶原酶-2,因其酶促能力,特别是其分解纤维状 I、II 和 III 型胶原蛋白的能力而受到认可。这种酶活性表明 MMP-8 在富含胶原蛋白的组织(如结缔组织、软骨和骨)的重塑和周转中发挥着重要作用。通过降解这些纤维状胶原蛋白,MMP-8 可以促进组织重塑、伤口愈合和炎症消退等过程。了解 MMP-8 的精确功能和调节可以为其参与胶原蛋白代谢和组织重塑提供有价值的见解,从而可能为以异常胶原蛋白降解或积累为特征的疾病提供治疗机会。

生物活性

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2. The specific activity is 8505.224 pmol/min/µg, as measured under the described conditions.

种属

Human

表达系统

HEK293

标签

C-10*His

蛋白编号

P22894 (F21-G467)

基因 ID
蛋白结构
N-term
MMP-8 (F21-G467)
Accession # P22894
10*His
C-term
同用名
Neutrophil collagenase; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; MMP8; CLG1
氨基酸序列

FPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG

分子量

approximately 64.09 kDa

纯度
  • Greater than 90% as determined by reducing SDS-PAGE.
性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

MMP-8 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
MMP-8 Protein, Human (HEK293, His)
目录号:
HY-P72507
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