1. 重组蛋白
  2. Receptor Proteins
  3. MPZL1 蛋白, Human (HEK293, His)

MPZL1 蛋白, Human (HEK293, His)

目录号: HY-P70220
COA 产品使用指南

MPZL1 蛋白是一种细胞表面受体,通过将 PTPN11/SHP-2 招募到细胞膜来参与信号转导。MPZL1 蛋白, Human (HEK293, His) 是重组的 MPZL1 蛋白,由 HEK293 表达,带有 C-6*His 标签。MPZL1 蛋白, Human (HEK293, His) 全长 127 个氨基酸,分子量为 20-28 kDa。

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规格 价格 是否有货 数量
10 μg ¥500 In-stock
50 μg ¥1050 In-stock
100 μg   询价  

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描述

MPZL1 protein is a cell surface receptor that participates in signal transduction by recruiting PTPN11/SHP-2 to the cell membrane. MPZL1 Protein, Human (HEK293, His) is the recombinant human-derived MPZL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MPZL1 Protein, Human (HEK293, His) is 127 a.a., with molecular weight of 20-28 kDa.

研究背景

MPZL1 是一种复杂参与信号转导过程的细胞表面受体,在将 PTPN11/SHP-2 募集到细胞膜方面发挥着关键作用,将其自身确立为 PTPN11/SHP-2 的推定底物。作为刀豆蛋白 A (ConA) 的主要受体,MPZL1 有助于 ConA 诱导的细胞信号传导,可能涉及 Src 家族酪氨酸蛋白激酶。同工型 3 变体似乎发挥显性负效应,抑制 ConA 诱导的 MPZL1 酪氨酸磷酸化。值得注意的是,同工型 1 与同工型 2 和同工型 3 不同,涉及整合素介导的细胞运动的调节。该受体还与磷酸化 PTPN11/SHP-2 相互作用,强调其在信号转导级联中的多方面参与。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

O95297 (S36-V162)

基因 ID
蛋白结构
N-term
MPZL1 (S36-V162)
Accession # O95297
6*His
C-term
同用名
rHuMyelin protein zero-like protein 1/MPZL1, His; Myelin protein zero-like 1; isoform CRA_b; cDNA FLJ78597; highly similar to Homo sapiens myelin protein zero-like 1 (MPZL1); transcript variant 1; mRNA ; cDNA; FLJ96614; Homo sapiens myelin protein zero-like 1 (MPZL1); Mrna
氨基酸序列

SALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPV

分子量

20-28 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

MPZL1 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
MPZL1 Protein, Human (HEK293, His)
目录号:
HY-P70220
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