Neuregulin-4/NRG4 蛋白, Human

Neuregulin-4 (NRG4) Protein, a low-affinity ligand for the ERBB4 tyrosine kinase receptor, serves as a signaling molecule that recruits ERBB1 and ERBB2 coreceptors. This recruitment leads to ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 specifically interacts with the ERBB4 receptor, mediating cellular responses through its activation, without binding to ERBB1, ERBB2, and ERBB3 receptors. Neuregulin-4/NRG4 Protein, Human is the recombinant human-derived Neuregulin-4/NRG4 protein, expressed by E. coli , with tag free. The total length of Neuregulin-4/NRG4 Protein, Human is 61 a.a., with molecular weight of ~6.7 KDa.

Neuregulin-4 (NRG4) 是 ERBB4 酪氨酸激酶受体的低亲和力配体，充当信号分子，同时招募 ERBB1 和 ERBB2 辅助受体。这种募集导致配体刺激的酪氨酸磷酸化和随后的 ERBB 受体激活。值得注意的是，NRG4 不与 ERBB1、ERBB2 和 ERBB3 受体结合。它与 ERBB4 受体特异性相互作用，通过激活该特定受体来介导细胞反应。

Measured in a cell proliferation assay using Raji human Burkitt's lymphoma cells. The ED₅₀ for this effect is 0.0144 μg/mL, corresponding to a specific activity is 6.944×10⁴ units/mg.

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  Measured in a cell proliferation assay using Raji human Burkitt's lymphoma cells. The ED₅₀ this effect is 0.0144 μg/mL, corresponding to a specific activity is 6.944×10^4 units/mg.

Human

E. coli

Tag Free

Q8WWG1 (GP&P2-F62)

145957  [NCBI]

GPPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLF

Approximately 6.7 kDa.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 50 mM NaCl, pH 7.2 or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.