Neuropilin-1 蛋白, Cynomolgus (HEK293)

Neuropilin-1 Protein, a transmembrane glycoprotein, regulates axon guidance, angiogenesis, neuronal development, and immune responses. Neuropilin-1 can interacts with VEGF and semaphorins, and promote the growth, survival, and self-renewal of tumors. Neuropilin-1 also acts as an entry factor and potentiate SARS-CoV-2 and Epstein-Barr virus (EBV) infectivity. Furthermore, Neuropilin-1 acts as a co-receptor for TGF-β, and enhances TGF-β activity via the SMAD2/3 signaling pathway^[1][2][3]. Neuropilin-1 Protein, Cynomolgus (HEK293) is the recombinant cynomolgus-derived Neuropilin-1 protein, expressed by HEK293, with amino acids (LEVLFQ) at the C-terminus.

Neuropilin-1 蛋白是一种跨膜糖蛋白。在小鼠中，NRP1 在胸腺来源的 Tregs 上选择性表达，并增强免疫抑制功能。在人类中，NRP1 主要表达于浆细胞样树突状细胞 (pDC) 上，有助于启动免疫反应，此外还表达于从二级淋巴结分离的 T 调节细胞 (Treg) 子集上^[1]。
Neuropilin-1 转导 VEGF 以及 VEGFR 家族成员的信号。Neuropilin-1 与 VEGF 和信号蛋白相互作用，可以促进肿瘤的生长、存活和自我更新。例如，Neuropilin-1 可与血管内皮细胞中的 VEGFR2 复合，诱导血管通透性和血管生成^[3]。
Neuropilin-1 还充当进入因子并增强 SARS-CoV-2 的感染性。此外，Neuropilin-1 是 Epstein-Barr 病毒 (EBV) 感染鼻咽上皮细胞的受体，并增强 EBV 感染^[2][3]。Neuropilin-1 通过与 Semaphorin-3A (一种在神经系统和脉管系统中广泛存在的蛋白质) 相互作用，在轴突引导和修剪中发挥核心作用^[3]。
此外，Neuropilin-1 作为 TGF-β 的共同受体，并通过 SMAD2/3 信号通路增强 TGF-β 活性。Neuropilin-1 可以激活非活性潜伏形式 (LAP-TGF-β)，并促进免疫抑制^[1]。
Neuropilin-1 在血管生成、神经元发育和免疫反应调节中发挥着重要作用。

Cynomolgus

HEK293

Tag Free

G7PEQ1 (M1-G613, with amino acids (LEVLFQ) at the C-terminus)

102145235

Partial

Approximately 67-77 kDa,based on SDS-PAGE under reducing conditions.

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Chaudhary B, et al. Neuropilin 1: function and therapeutic potential in cancer. Cancer Immunol Immunother. 2014 Feb;63(2):81-99.

  [2]. Guo HF, Vander Kooi CW. Neuropilin Functions as an Essential Cell Surface Receptor. J Biol Chem. 2015 Dec 4;290(49):29120-6.  [Content Brief]

  [3]. Mayi BS, et al. The role of Neuropilin-1 in COVID-19. PLoS Pathog. 2021 Jan 4;17(1):e1009153.  [Content Brief]