OX40/TNFRSF4 蛋白, Mouse (HEK293, His-Avi)

OX40 (TNFRSF4), is a receptor for OX40 Ligand. OX40 is preferentially expressed by T cells. OX40 can be activated by OX40 Ligand, thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs^[1][2]. OX40/TNFRSF4 Protein, Mouse (His-Avi) is a recombinant mouse OX40 (V20-P211) with C-terminal Avi and His tag, which is produced in HEK293.

OX40 (TNFRSF4) 是 TNFR 超家族的成员，是 OX40 配体的受体。OX40优先由T细胞表达，但也在自然杀伤T细胞、自然杀伤细胞、中性粒细胞和人气道平滑肌细胞中发现。小鼠 OX40 与大鼠具有 90% 的 aa 序列同一性。小鼠 OX40 与人类<30% aa 序列同一性^[1]。
OX40 配体可以激活 OX40，从而充当 T 细胞共刺激分子。OX40-OX40配体相互作用促进效应T细胞存活并有效诱导记忆T细胞生成，增强Tfh对B细胞的辅助功能，并促进DC的分化和成熟^{[1]< /sup>[2]}。
OX40配体与OX40之间的相互作用对于抗原特异性记忆T细胞的产生至关重要，并诱导宿主抗肿瘤免疫^[3]。但 OX40 和 OX40L 的过度上调可能会导致 Tfh 细胞异常激活和自身抗体过度产生，从而导致自身免疫性疾病^[1]。例如，OX40 与 OX40 配体的相互作用对于小鼠过敏性炎症的 Th1 和 Th2 反应至关重要^[4]。

OX4 increases expression of RANTES protein in HUVECs^[5].

OX4 (rat, 5 μg/kg, i.c.v) increases expression of the OX4L, reduces the neuronal apoptosis, and improves short and long-term neurological function deficits^[6].

Mouse

HEK293

C-Avi;C-His

P47741 (V20-P211)

22163  [NCBI]

50-60 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Kaur D, et al. OX40/OX40 ligand interactions in T-cell regulation and asthma. Chest. 2012 Feb;141(2):494-499.  [Content Brief]

  [2]. Fu N, et al. The OX40/OX40L Axis Regulates T Follicular Helper Cell Differentiation: Implications for Autoimmune Diseases. Front Immunol. 2021 Jun 21;12:670637.  [Content Brief]

  [3]. Buglio D, et al. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma. Blood. 2011 Mar 10;117(10):2910-7.  [Content Brief]

  [4]. Arestides RS, et al. Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation. Eur J Immunol. 2002 Oct;32(10):2874-80.  [Content Brief]

  [5]. Kotani A, et al. Signaling of gp34 (OX40 ligand) induces vascular endothelial cells to produce a CC chemokine RANTES/CCL5. Immunol Lett. 2002 Oct 21;84(1):1-7.  [Content Brief]

  [6]. Wu LY, et al. Recombinant OX40 attenuates neuronal apoptosis through OX40-OX40L/PI3K/AKT signaling pathway following subarachnoid hemorrhage in rats. Exp Neurol. 2020 Apr;326:113179.  [Content Brief]