PARM-1 蛋白, Human (HEK293, His)

PARM-1 Protein is a highly glycosylated, mucin-like type 1 transmembrane protein primarily located at the plasma membrane and in the endocytic pathway. PARM-1 is also a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response, and its presence in most human tissues with especially high expression in heart, kidney and placenta. PARM-1 may regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. PARM-1 Protein, Human (HEK293, His) is the recombinant human-derived PARM-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of PARM-1 Protein, Human (HEK293, His) is 238 a.a., with molecular weight of ~25.7 kDa.

前列腺雄激素调节粘蛋白样蛋白 1 (PARM-1) 是一种高度糖基化的粘蛋白样 1 型跨膜蛋白，主要位于质膜和内吞途径中。PARM-1 也是一种促增殖和抗凋亡糖蛋白，参与内质网 (ER) 应激反应，它存在于大多数人体组织中，尤其在心脏、肾脏和胎盘中高表达。PARM-1 通过充当黄体酮代谢的新型调节剂来促进排卵和/或黄体功能。PARM-1 可能调节 TLP1 表达和端粒酶活性，从而使某些前列腺细胞能够抵抗凋亡。此外，人 PARM-1在前列腺癌细胞系中的异位表达增加了细胞增殖，从而表明其在前列腺和前列腺癌的生理生物学中的作用^{[1][2][13][4]}。

Human

HEK293

C-His

AAH13294 (L21-S258)

25849  [NCBI]

Approximately 25.7 kDa

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.