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  4. PIK3R3 蛋白, Human (Sf9, His, GST)

PIK3R3 蛋白, Human (Sf9, His, GST)

目录号: HY-P701744
产品使用指南

PIK3R3 蛋白通过其 SH2 结构域与磷酸化蛋白酪氨酸激酶相互作用，至关重要地调节其激酶活性。在胰岛素刺激期间，PIK3R3 与 IRS-1 结合。它作为具有 p110 催化亚基的异二聚体运行，与 AXL 相互作用，扩展其功能网络。PIK3R3 蛋白, Human (Sf9, His, GST) 是重组的 PIK3R3 蛋白，由 Sf9 insect cells 表达，带有 N-8*His, N-GST 标签。PIK3R3 蛋白, Human (Sf9, His, GST) 全长 460 个氨基酸。

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100 μg   询价  

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描述

PIK3R3 protein, through its SH2 domain, interacts with phosphorylated protein-tyrosine kinases, crucially regulating their kinase activity. During insulin stimulation, PIK3R3 binds to IRS-1. Operating as a heterodimer with a p110 catalytic subunit, it interacts with AXL, expanding its functional network. PIK3R3 Protein, Human (Sf9, His, GST) is the recombinant human-derived PIK3R3 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of PIK3R3 Protein, Human (Sf9, His, GST) is 460 a.a., .
研究背景

PIK3R3 蛋白通过其 SH2 结构域与激活的（磷酸化）蛋白酪氨酸激酶结合，在调节其激酶活性中发挥关键作用。此外，在胰岛素刺激过程中，PIK3R3 与 IRS-1 形成结合。该蛋白以异二聚体的形式发挥作用，包含调节亚基 (PIK3R3) 和 p110 催化亚基（PIK3CA、PIK3CB 或 PIK3CD）。此外，PIK3R3 展示了与 AXL 的相互作用，为其功能网络做出了贡献。
种属

Human
表达系统

Sf9 insect cells
标签

N-8*His;N-GST
蛋白编号

Q92569 (Y2-R461)
基因 ID

8503
蛋白结构
N-term
8*His-GST
PIK3R3 (Y2-R461)
Accession # Q92569
C-term
同用名
PIK3R3; Phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase regulatory subunit gamma; PI3K regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

PIK3R3 Protein, Human (Sf9, His, GST) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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