Prostatic acid Phosphatase/ACPP Protein-VLP, Human (386a.a, HEK293, His)

Prostatic acid phosphatase (ACPP) operates as a versatile tyrosine phosphatase under acidic conditions (pH 4-6), dephosphorylating various substrates, including orthophosphate monoesters. With lipid phosphatase activity, ACPP inactivates lysophosphatidic acid in seminal plasma. In prostate cancer, it acts as a tumor suppressor by dephosphorylating ERBB2, deactivating MAPK signaling, and controlling cancer-related processes. ACPP also exhibits ecto-5'-nucleotidase activity in dorsal root ganglion neurons, suggesting a role in pain modulation by generating adenosine from AMP. Prostatic acid Phosphatase/ACPP Protein-VLP, Human (386a.a, HEK293, His) is the recombinant human-derived Prostatic acid Phosphatase/ACPP protein-VLP, expressed by HEK293, with N-10*His labeled tag. The total length of Prostatic acid Phosphatase/ACPP Protein-VLP, Human (386a.a, HEK293, His) is 386 a.a., with molecular weight of 47.5 kDa.

前列腺酸性磷酸酶 (ACPP) 是一种在酸性条件 (pH 4-6) 下工作的非特异性酪氨酸磷酸酶，证明了其在去磷酸化多种底物方面的多功能性，包括烷基、芳基和酰基正磷酸单酯以及磷酸化底物。蛋白质。值得注意的是，ACPP 具有脂质磷酸酶活性，有助于精浆中溶血磷脂酸的失活。ACPP 作为前列腺癌中的肿瘤抑制因子，在 ERBB2 去磷酸化和 MAPK 介导的信号传导失活方面发挥着至关重要的作用，从而控制与癌症进展有关的细胞过程。除了其酪氨酸磷酸酶活性外，ACPP 还在背根神经节神经元中展示了 5'-核苷酸酶活性，从 AMP 产生腺苷。这种附加功能表明腺苷在疼痛调节中发挥作用，其中腺苷充当疼痛抑制剂，强调了 ACPP 在细胞过程中的多方面性质。

Human

HEK293

N-10*His

P15309 (K33-I418)

55  [NCBI]

KELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELGEYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETLKSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGVLVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCPLERFAELVGPVIPQDWSTECMTTNSHQVLKVIFAVAFCLISAVLMVLLFIHIRRGLCWQRESYGNI

47.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.