PTK7 蛋白, Mouse (HEK293, His)

Ptk7 Protein is a cell surface receptor that plays a crucial role in regulating cell migration and tissue development. Dysregulation of Ptk7 Protein has been associated with various diseases, including cancer and developmental disorders. Targeting Ptk7 Protein may offer potential therapeutic interventions in these conditions by modulating cell migration, inhibiting tumor growth, and promoting normal tissue development. PTK7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PTK7 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of PTK7 Protein, Mouse (HEK293, His) is 674 a.a., with molecular weight of 83-130 kDa.

Ptk7 蛋白是一种无活性的酪氨酸激酶，在 Wnt 信号通路中发挥着至关重要的作用，特别是在非规范（Wnt/平面细胞极性信号传导）和规范 Wnt 信号通路中。它参与多种细胞过程，包括细胞粘附、迁移、极性、增殖、肌动蛋白细胞骨架重组和凋亡。Ptk7 蛋白还有助于胚胎发生、上皮组织组织和血管生成。此外，它还与 CTNNB1 相互作用，进一步凸显了它在 Wnt 信号传导中的重要性。

Measured by its binding ability in a functional ELISA. Recombinant Mouse PTK7/CCK4 Fc Chimera binds Biotinylated Recombinant Mouse Wnt-3a. The ED₅₀ for this effect is 7.183 μg/mL.

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  Measured by its binding ability in a functional ELISA. Recombinant Mouse PTK7/CCK4 Fc Chimera binds Biotinylated Recombinant Mouse Wnt-3a . The ED₅₀ for this effect is7.183 μg/mL.

Mouse

HEK293

C-10*His

Q8BKG3-1 (A23-T696)

71461  [NCBI]

AIVFIKEPSSQDALQGRRALLRCEVEAPDPVHVYWLLNGVPVQDTERRFAQGSSLSFAAVDRLQDSGAFQCVARDNVTGEEVRSTNASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDDQSTHTVSSRERNLTLRPASPEHSGLYSCCAHNAFGQACSSQNFTLSVADESFARVVLAPQDVVVARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRRAVVFANGSLLLTQVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDMLPFEPRVFIAGDEERVTCPAPQGLPTPSVWWEHAGVPLPAHGRVHQKGLELVFVTIAESDTGVYTCHASNLAGQRRQDVNITVATVPTWLRKPQDSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLISEDSRFEVSKNGTLRINSVEVYDGTLYRCVSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTVKWVRADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNEPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLRCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGSYTCIAGNSCNIRHTEAPLLVVDKPVMEDSEGPGSPPPYKMIQT

83-130 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.