1. 重组蛋白
  2. CAR-T related Proteins CD Antigens Receptor Proteins
  3. B Cell CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins Siglec
  4. Siglec-2/CD22
  5. Siglec-2/CD22 蛋白, Human (HEK293, His)

Siglec-2/CD22 蛋白, Human (HEK293, His)

目录号: HY-P72019
COA 产品使用指南

Siglec-2/CD22 蛋白介导 B 细胞相互作用,并可能指导 B 细胞在淋巴组织内的定位。它识别唾液酸化糖蛋白,尤其是 α-2,6-连接唾液酸,并参与细胞表面的顺式相互作用。Siglec-2/CD22 蛋白, Human (HEK293, His) 是重组的 Siglec-2/CD22 蛋白,由 HEK293 表达,带有 C-6*His 标签。Siglec-2/CD22 蛋白, Human (HEK293, His) 全长 668 个氨基酸,分子量为 77-110 kDa。

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描述

The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-2/CD22 Protein, Human (HEK293, His) is 668 a.a., with molecular weight of 77-110 kDa.

研究背景

Siglec-2/CD22 蛋白是 B 细胞相互作用中的关键介质,可能在 B 细胞在淋巴组织内的定位中发挥作用。它以其结合唾液酸化糖蛋白(包括 CD45)的能力而闻名,它表现出对 α-2,6-连接唾液酸的偏好。唾液酸识别位点可能被同一细胞表面上唾液酸的顺式相互作用所掩盖。在免疫反应过程中,配体诱导的酪氨酸磷酸化表明其参与 B 细胞抗原受体信号传导的调节。该蛋白的多方面作用包括通过与 Src 家族酪氨酸激酶相互作用进行正向调节,同时作为抑制性受体,通过其 SH2 结构域招募细胞质磷酸酶,通过信号分子的去磷酸化来阻断信号转导。Siglec-2/CD22 主要作为异构体 CD22-β 的单体存在,也可以与较短的异构体形成异二聚体。它与 PTPN6/SHP-1、LYN、SYK、PIK3R1/PIK3R2、PLCG1、GRB2、INPP5D 和 SHC1 等关键分子之间复杂的相互作用,特别是在磷酸化时,突显了其在协调 B 细胞内复杂信号网络中的关键作用。进一步的研究对于揭示 Siglec-2/CD22 在 B 细胞调节和免疫反应中的精确分子途径和功能后果至关重要。

生物活性

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/mL can bind Anti-CD22 rabbit monoclonal antibody and the EC50 is <1.661 ng/mL.

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

P20273 (R20-R687)

基因 ID

933  [NCBI]

蛋白结构
N-term
CD22 (R20-R687)
Accession # P20273
6*His
C-term
同用名
B-cell receptor CD22; BL-CAM; Siglec-2; CD22; SIGLEC2
氨基酸序列

DSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRR

分子量

77-110 kDa

纯度
  • Greater than 96% as determined by reducing SDS-PAGE.
性状

无菌粉末.

组分

Lyophilized from a 0.2 μm solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Siglec-2/CD22 Protein, Human (HEK293, His)
目录号:
HY-P72019
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