SLPI 蛋白, Human (107a.a, sf9, His, solution)

The SLPI protein is an acid-stable protease inhibitor that has shown strong affinity for trypsin, chymotrypsin, elastase, and cathepsin G in multiple studies. It plays a critical regulatory role in inflammatory and immune responses following bacterial infection and Listeria monocytogenes infection. SLPI Protein, Human (107a.a, sf9, His, solution) is the recombinant human-derived SLPI protein, expressed by Sf9 insect cells , with N-6*His labeled tag.

多种研究表明，SLPI 是一种酸稳定的蛋白酶抑制剂，对胰蛋白酶、胰凝乳蛋白酶、弹性蛋白酶和组织蛋白酶 G 具有强大的亲和力。它在调节细菌感染以及细胞内寄生虫 L.major 感染后的炎症和免疫反应中发挥着至关重要的作用。此外，SLPI 有助于下调对细菌脂多糖 (LPS) 的反应（通过相似性），并参与调节 NF-κ-B 的激活，从而影响炎症反应。值得注意的是，SLPI 对分枝杆菌具有抗菌活性，但对沙门氏菌没有抗菌活性，有助于对结核分枝杆菌感染的正常抵抗力。它对于正常抵抗 L.major 感染也至关重要，并且在伤口愈合中发挥着关键作用，可能是通过调节蛋白酶活性来防止组织损伤（通过相似性）。此外，与 ELANE 合作，SLPI 是骨髓细胞正常分化和增殖所必需的，并且它与 GRN 相互作用，保护颗粒体蛋白前体免受蛋白水解。

Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate Mca-RPKPVE-Nval-WRK (Dnp)-NH2 and the IC₅₀ value is <1 nM.

Human

Sf9 insect cells

N-6*His

P03973 (S26-A132)

6590  [NCBI]

Full Length of Mature Protein

Approximately 19 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.