SULT2A1 蛋白, Human (His)

The SULT2A1 protein utilizes PAPS for critical sulfonation of steroids and bile acids in the liver and adrenal glands. Its multifunctional activity extends to a variety of compounds, enhancing its water solubility to facilitate renal excretion. SULT2A1 Protein, Human (His) is the recombinant human-derived SULT2A1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SULT2A1 Protein, Human (His) is 284 a.a., with molecular weight of 34-38 kDa.

SULT2A1 蛋白是一种利用 3'-磷酸-5'-腺苷酸硫酸盐 (PAPS) 作为磺酸盐供体的磺基转移酶，在肝脏和肾上腺内类固醇和胆汁酸的磺化过程中充当重要的介质。SULT2A1 具有多种酶活性，可促进多种类固醇和甾醇的硫酸化，包括孕烯醇酮、雄酮、DHEA、胆汁酸、胆固醇以及许多具有醇和酚官能团的异生物质。这种磺化过程增强了这些化合物的水溶性，促进它们的肾脏排泄；然而，它也有可能导致生物活化，形成活性代谢物。SULT2A1 的多方面作用包括维持类固醇和脂质稳态、在胆汁酸代谢中发挥关键作用以及催化强效致癌多环芳基甲醇的代谢激活。SULT2A1 的多种底物特异性强调了其在调节基本生理过程中的重要性及其在具有致癌特性的化合物的代谢激活中的潜在参与。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-6*His

Q06520 (S2-E285)

6822  [NCBI]

SDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE

34-38 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.