2. 重组蛋白
  3. Receptor Proteins
  4. Thrombin Receptor/PAR1 蛋白, Human (HEK293, His)

Thrombin Receptor/PAR1 蛋白, Human (HEK293, His)

目录号: HY-P73612
产品使用指南

凝血酶受体/PAR1 蛋白是活化凝血酶的高亲和力受体，与 G 蛋白偶联以刺激磷酸肌醇水解。这种信号机制表明它参与血小板活化，这对于止血和血栓形成至关重要。Thrombin Receptor/PAR1 蛋白, Human (HEK293, His) 是重组的 凝血酶受体/PAR1 蛋白，由 HEK293 表达，带有 C-His 标签。Thrombin Receptor/PAR1 蛋白, Human (HEK293, His) 全长 81 个氨基酸，分子量约为 ~10.2 kDa。

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描述

The thrombin receptor/PAR1 protein is a high-affinity receptor for activated thrombin that is coupled to G proteins to stimulate phosphoinositide hydrolysis. This signaling mechanism suggests its involvement in platelet activation, which is critical for hemostasis and thrombosis. Thrombin Receptor/PAR1 Protein, Human (HEK293, His) is the recombinant human-derived Thrombin Receptor/PAR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Thrombin Receptor/PAR1 Protein, Human (HEK293, His) is 81 a.a., with molecular weight of ~10.2 kDa.
研究背景

凝血酶受体/PAR1 蛋白作为活化凝血酶的高亲和力受体，与 G 蛋白形成偶联，进而刺激磷酸肌醇水解。这种复杂的信号机制表明它可能参与血小板活化，这是止血和血栓形成的关键过程。此外，凝血酶受体/PAR1 蛋白可能在血管发育中发挥作用，表明其在控制血管形成和维持的复杂调节途径中的重要性。该受体的双重功能突出了其在止血过程和血管生物学更广泛方面的作用，强调了其在维持心血管稳态中的重要性。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

P25116/NP_001983.2 (A22-T102)
基因 ID
蛋白结构
N-term
PAR1 (A22-T102)
Accession # P25116/NP_001983.2
His
C-term
同用名
Cf2r; CF2RHTR; F2R; HTR; PAR1; Protease-Activated Receptor 1
分子量

Approximately 10.2 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Thrombin Receptor/PAR1 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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