1. 重组蛋白
  2. CD Antigens
  3. Macrophage CD Proteins Dendritic Cell CD Proteins Endothelial cell CD Proteins
  4. BDCA-3/CD141
  5. Thrombomodulin 蛋白, Human (HEK293, His, solution)

Thrombomodulin 蛋白, Human (HEK293, His, solution)

目录号: HY-P70724
COA 产品使用指南

血栓调节蛋白是一种内皮细胞受体,与凝血酶形成 1:1 复合物,对于凝血调节至关重要。该复合物激活蛋白 C,将其转化为蛋白 Ca。然后,蛋白 Ca 抑制凝血级联的活化辅助因子(因子 Va 和因子 VIIIa),抑制凝血酶的产生。血栓调节蛋白与 ITGAL、ITGAM 和 ITGB2 的相互作用强调了其在免疫反应调节中的作用。Thrombomodulin 蛋白, Human (HEK293, His, solution) 是重组的 血栓调节蛋白,由 HEK293 表达,带有 C-6*His 标签。Thrombomodulin 蛋白, Human (HEK293, His, solution) 全长 497 个氨基酸,分子量约为 ~72 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 μg ¥2150 In-stock
50 μg ¥6000 In-stock
100 μg   询价  

* Please select Quantity before adding items.

Thrombomodulin Protein, Human (HEK293, His, solution) 相关产品:

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Thrombomodulin, an endothelial cell receptor, forms a 1:1 complex with thrombin, vital for coagulation regulation. This complex activates protein C, converting it to protein Ca. Protein Ca then inhibits the activated cofactors (factor Va and factor VIIIa) of the coagulation cascade, suppressing thrombin generation. Thrombomodulin's interaction with ITGAL, ITGAM, and ITGB2 emphasizes its role in immune response modulation. Thrombomodulin Protein, Human (HEK293, His, solution) is the recombinant human-derived Thrombomodulin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Thrombomodulin Protein, Human (HEK293, His, solution) is 497 a.a., with molecular weight of ~72 kDa.

研究背景

血栓调节蛋白是一种独特的内皮细胞受体,与凝血酶建立精确的 1:1 化学计量复合物,在凝血调节中发挥着至关重要的作用。该复合物促进蛋白 C 转化为其活化形式蛋白 Ca。一旦被激活,蛋白 Ca 通过裂解凝血级联的激活辅助因子(即因子 Va 和因子 VIIIa)发挥作用,有效抑制凝血酶的产生。血栓调节蛋白与 ITGAL、ITGAM 和 ITGB2 的相互作用进一步强调了其参与调节免疫反应。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

P07204 (A19-S515)

基因 ID
蛋白结构
N-term
Thrombomodulin (A19-S515)
Accession # P07204
6*His
C-term
同用名
Thrombomodulin; THBD; TM; Fetomodulin; CD141; THRM
氨基酸序列

APAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHS

分子量

Approximately 72 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

溶液.

组分

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

内毒素含量

<1 EU/μg, determined by LAL method.

保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Thrombomodulin Protein, Human (HEK293, His, solution)
目录号:
HY-P70724
需求量: