Thrombomodulin 蛋白, Mouse (HEK293, His)

Thrombomodulin is an endothelial cell receptor that forms a 1:1 complex with thrombin and is essential for the activation of protein C to protein Ca. Protein Ca cleaves coagulation cascade cofactors and reduces thrombin generation. Thrombomodulin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Thrombomodulin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Thrombomodulin Protein, Mouse (HEK293, His) is 501 a.a., with molecular weight of 85-90 kDa.

血栓调节蛋白作为一种特定的内皮细胞受体，与凝血酶形成 1:1 化学计量复合物。该复合物在蛋白 C 转化为其活化形式蛋白 Ca 的过程中发挥着关键作用。激活后，蛋白 Ca 会裂解凝血级联的激活辅助因子，即因子 Va 和因子 VIIIa，导致凝血酶总体产量减少。血栓调节蛋白与 ITGAL、ITGAM 和 ITGB2 的相互作用进一步强调了其在介导细胞相互作用中的作用，可能影响免疫反应。这种复杂的相互作用强调了血栓调节蛋白在调节凝血途径和维持止血平衡方面的重要性。

Mouse

HEK293

C-6*His

P15306 (L17-S517)

21824  [NCBI]

LSALAKLQPTGSQCVEHECFALFQGPATFLDASQACQRLQGHLMTVRSSVAADVISLLLSQSSMDLGPWIGLQLPQGCDDPVHLGPLRGFQWVTGDNHTSYSRWARPNDQTAPLCGPLCVTVSTATEAAPGEPAWEEKPCETETQGFLCEFYFTASCRPLTVNTRDPEAAHISSTYNTPFGVSGADFQTLPVGSSAAVEPLGLELVCRAPPGTSEGHWAWEATGAWNCSVENGGCEYLCNRSTNEPRCLCPRDMDLQADGRSCARPVVQSCNELCEHFCVSNAEVPGSYSCMCETGYQLAADGHRCEDVDDCKQGPNPCPQLCVNTKGGFECFCYDGYELVDGECVELLDPCFGSNCEFQCQPVSPTDYRCICAPGFAPKPDEPHKCEMFCNETSCPADCDPNSPTVCECPEGFILDEGSVCTDIDECSQGECFTSECRNFPGSYECICGPDTALAGQISKDCDPIPVREDTKEEEGSGEPPVSPTPGSPTGPPSARPVHS

85-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0 .

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.