TIM-3/HAVCR2 蛋白, Human (HEK293, Fc-Avi)

T cell immunoglobulin mucin-3 is an inhibitory receptor, and inhibits T cell functions. TIM-3 regulates immune responses in autoimmunity and cancer. TIM-3 has multiple different ligands: galectin 9, phosphatidylserine (PtdSer), CEACAM1 and HMGB1. The TIM-3-ligand axis is critical in the pathogenesis of numerous conditions, including autoimmune diseases, infections, cancers, transplant rejection, and chronic inflammation^{[1][2][3][4][5]}. TIM-3/HAVCR2 Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived TIM-3/HAVCR2 protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of TIM-3/HAVCR2 Protein, Human (HEK293, Fc-Avi) is 179 a.a., with molecular weight of 60-75 kDa.

T 细胞免疫球蛋白 mucin-3 (TIM-3) 属于 Ig 超家族。TIM-3 通常由多种小鼠和人类免疫细胞类型表达。TIM-3 最初是在产生 IFN-γ 的 Th1 和 Tc1 细胞上发现的。TIM-3 作为抑制性受体，抑制 T 细胞功能。TIM-3 与自身免疫和癌症中免疫反应的调节有关^[1][5]。
TIM-3 具有多种不同的配体：半乳糖凝集素 9、磷脂酰丝氨酸 (PtdSer)、CEACAM1 和 HMGB1，这些配体与 TIM3 胞外免疫球蛋白 V 结构域上的不同区域结合。TIM-3 配体轴在多种疾病的发病机制中至关重要，包括自身免疫性疾病、感染、癌症、移植排斥和慢性炎症。例如，TIM-3 与 galectin-9 的结合可以下调 Th1 反应^[2][3][4]。此外，Tim-3 表达失调与自身免疫性疾病相关^[5]。

Human

HEK293

C-Avi;C-hFc

AAL65157.1(S22-R200)

84868  [NCBI]

SEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMNDEKFNLKLVIKPAKVTPAPTLQRDFTAAFPRMLTTRGHGPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIR

60-75 kDa

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.