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  3. TMEM119 蛋白, Human (P. pastoris, His)

TMEM119 蛋白, Human (P. pastoris, His)

目录号: HY-P704155
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TMEM119 蛋白对于骨形成至关重要,有助于成肌细胞分化为成骨细胞。它通过增强 BMP2 的产生并与 BMP-RUNX2 通路相互作用来诱导定型和分化。TMEM119 蛋白, Human (P. pastoris, His) 是重组的 TMEM119 蛋白,由 P. pastoris 表达,带有 N-6*His 标签。

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描述

The TMEM119 protein is critical in bone formation and helps myoblasts differentiate into osteoblasts. It induces commitment and differentiation by enhancing BMP2 production and interacting with the BMP-RUNX2 pathway. TMEM119 Protein, Human (P. pastoris, His) is the recombinant human-derived TMEM119 protein, expressed by P. pastoris, with N-6*His labeled tag.

研究背景

TMEM119蛋白在骨形成和骨的正常矿化中起着至关重要的作用,积极参与成肌细胞向成骨细胞的分化。建议通过增强 BMP2 的产生以及与 BMP-RUNX2 通路的相互作用来诱导成肌细胞定向分化为成骨细胞。TMEM119 还通过上调 ATF4(该过程中的核心转录因子)的表达来促进成骨细胞分化。除了在骨骼发育中的作用之外,TMEM119 还被认为对于正常的精子发生和晚期睾丸分化至关重要。从分子角度来看,TMEM119 与成骨的关键调节因子(包括 SMAD1、SMAD5 和 RUNX2)相互作用,强调其在骨形成和精子发生过程中的复杂参与,强调其在生理发育的多个方面的重要性。

种属

Human

表达系统

P. pastoris

标签

N-6*His

蛋白编号

Q4V9L6 (R26-M96)

基因 ID

338773

蛋白结构
N-term
6*His
TMEM119 (R26-M96)
Accession # Q4V9L6
C-term
蛋白长度

Extracellular Domain

中文名
人跨膜蛋白 119
同用名
TMEM119; Transmembrane protein 119; Osteoblast induction factor (OBIF)
氨基酸序列

RSVPLKATFLEDVAGSGEAEGSSASSPSLPPPWTPALSPTSMGPQPITLGGPSPPTNFLDGIVDFFRQYVM

分子量

Approximately 9.4 kDa, based on SDS-PAGE under reducing conditions.

纯度

Greater than 85% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

TMEM119 Protein, Human (P. pastoris, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TMEM119 Protein, Human (P. pastoris, His)
目录号:
HY-P704155
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