TNF RII/TNFRSF1B 蛋白, Human (Biotinylated, HEK293, His)

TNFRII protein, a receptor with high affinity for TNFSF2/TNF-alpha and lower affinity for TNFSF1/lymphotoxin-alpha, plays a pivotal role in mediating TNF-alpha's metabolic effects. The TRAF1/TRAF2 complex recruits BIRC2 and BIRC3 to TNFRSF1B/TNFR2, modulating apoptotic pathways. Isoform 2 blocks TNF-alpha-induced apoptosis, suggesting a regulatory role in antagonizing its biological activity. TNFRII interacts with TRAF2, BMX, and activated XPNPEP3, adding complexity to its molecular associations and highlighting its involvement in downstream signaling cascades. TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived TNF RII/TNFRSF1B protein, expressed by HEK293 , with C-His labeled tag. The total length of TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) is 235 a.a., with molecular weight of 40-60 kDa.

TNFRII 蛋白作为受体，对 TNFSF2/TNF-α 具有高亲和力，对同源三聚体 TNFSF1/淋巴毒素-α 的亲和力低约 5 倍。 TRAF1/TRAF2 复合物将细胞凋亡抑制因子 BIRC2 和 BIRC3 募集至 TNFRSF1B/TNFR2，从而调节细胞凋亡途径。该受体在介导 TNF-α 诱导的大部分代谢作用中发挥着关键作用。值得注意的是，其亚型 2 表现出阻断 TNF-α 诱导的细胞凋亡的能力，表明在拮抗 TNF-α 的生物活性中具有调节作用。此外，TNFRII 与 TRAF2 结合，突显其参与下游信号级联反应。此外，与 BMX 和 XPNPEP3 激活形式的相互作用进一步增加了其分子关联的复杂性。

Human

HEK293

C-His

P20333-1 (L23-D257)

7133  [NCBI]

40-60 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.