TNFAIP8 蛋白, Human (His)

TNFAIP8 Protein functions as a negative regulator of apoptosis, inhibiting caspase-8 activity and suppressing TNF-mediated apoptosis without affecting procaspase-8 processing.This control prevents BID cleavage and subsequent caspase-3 activation, contributing to cellular survival mechanisms.TNFAIP8's role highlights its potential significance in apoptosis regulation and its implications for tumor development.TNFAIP8 Protein, Human (His) is the recombinant human-derived TNFAIP8 protein, expressed by E.coli , with N-His labeled tag.

TNFAIP8 蛋白作为细胞凋亡的负调节因子，与肿瘤进展有关。其功能作用包括通过抑制 caspase-8 活性来抑制 TNF 介导的细胞凋亡，同时不影响 procaspase-8 的加工。这反过来又会阻止 BID 裂解和随后的 caspase-3 激活。通过控制细胞凋亡途径中的关键成分，TNFAIP8 有助于细胞生存机制，强调其在细胞凋亡调节背景下的潜在意义及其对肿瘤发展的影响。

Human

E. coli

N-6*His

O95379-1 (M1-I198)

25816  [NCBI]

MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEENI

Approximately 24 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.0, 10% Glycerol, 10% trehalose, 0.02% Tween80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.