TSLP R 蛋白, Cynomolgus (HEK293, His)

TSLP R protein is the receptor of TSLP and cooperates with IL7R to form a complex that activates STAT3 and STAT5 to stimulate cell proliferation. This receptor also activates JAK2, which is critical for the development of the hematopoietic system. TSLP R Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TSLP R protein, expressed by HEK293 , with C-His labeled tag.

TSLPR 蛋白作为胸腺基质淋巴细胞生成素 (TSLP) 的受体发挥作用，并与 IL7R 合作形成功能复合物，通过激活 STAT3 和 STAT5 刺激细胞增殖。此外，该受体激活 JAK2，在造血系统的发育中发挥着至关重要的作用。TSLPR 受体以 CRLF2 和 IL7R 的异二聚体形式存在，是高亲和力三元复合物的重要组成部分，其中 TSLP 与 CRLF2/TSLPR 的结合是招募 IL7R 的机制先决条件，突出了其在复杂的三元复合物中的关键作用。对细胞反应和造血发育至关重要的信号通路。

Immobilized Cynomolgus TSLPR, His Tag at 0.5 μg/mL (100 μl/well) on the plate. Dose response curve for Anti-TSLPR Antibody, hFc Tag with the EC₅₀ of <13.3 ng/mL determined by ELISA.

Cynomolgus

HEK293

C-8*His

XP_045239630.1 (Q23-K231)

123571109  [NCBI]

Partial

42-52 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.